Numerical analysis of an equivalent heat transfer coefficient in a porous model for simulating a biological tissue in a hyperthermia therapy

Generalized dual-phase lag bioheat equations based on nonequilibrium heat transfer in living biological tissues

“…[10]. On the other hand, the thermal conductivity of blood (k b = 0.5W/m K) used by Yuan [24] agreed with other sources [25] and appeared to be reasonable. The diameter of the blood vessel and the porosity of the tissue were not available in Ref.…”

“…Therefore, the coupling factor can be obtained if the porosity, diameter of the vascular tube, and blood perfusion rate are available. Yuan [24] presented a numerical analysis of an equivalent heat transfer coefficient in a porous model for simulating a biological tissue in a hyperthermia therapy based on the nonequilibrium heat transfer model of Ref. [18].…”

“…Yuan [24] assumed that the thermophysical properties of blood and tissues are identical: k b = k s = 0.5W/m K, q b = q s = 1050 kg/m 3 , and c b = c s = 3770 J/kg K. The contributions of convective heat transfer and blood perfusion in blood-tissue coupling, coupling factor, and the phase lag times with the above properties are listed in Table 2. It can be seen that while the coupling between the blood and tissue is dominated by contribution of the convective heat transfer, the contribution of blood diffusion on coupling between blood and tissue ranges from 10% to 20%, depending on the blood perfusion rate.…”

The effects of magnetic nanoparticle properties on magnetic fluid hyperthermia

“…25,26 The blood temperature is always 37°C, a reasonable assumption since it travels rapidly enough to be relatively unaffected by any heating. 27 The blood perfusion is homogeneous throughout the healthy and affected tissue, since blood capillaries are typically homogeneously distributed in the tissue bed. 28 The MNP-loaded tissue experience a volumetric heating under an alternating magnetic field, while the perfusing blood abstracts heat from the tissue as long as the tissue temperature is above a threshold ͑the basal body temperature͒.…”

The numerical assessment of volume averaging method in heat transfer modeling of tissue-like porous media

“…One of these differences is the absence or presence of perfusion term in blood and tissue energy equations, and the other is the consideration of blood as the integrated fluid phase or separated arterial and venous phases. Accordingly, the porous mediabased studies of living tissue heat transfer can be categorized into four groups: two equation models without perfusion term [5][6][7][8][9][10][11][12][13][14][15][16][17][18], two equation models with perfusion term [19][20][21][22][23][24][25][26][27], three equation models without perfusion term [27,28], and three equation models with perfusion [29][30][31]. For better understanding and evaluation of these important differences, this paper establishes a vascular tissue with cylindrical geometry and relative anatomical similarity to human muscle tissues.…”