Numerical analysis and experimental study of terahertz solid immersion microscopy

Chernomyrdin, Nikita V.; Zhelnov, Vladislav A.; Kucheryavenko, Anna S.; Dolganova, Irina N.; Katyba, Gleb M.; Karasik, Valeriy E.; Reshetov, Igor V.; Zaytsev, Kirill I.

doi:10.1117/1.oe.59.6.061605

Cited by 31 publications

(19 citation statements)

References 92 publications

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“…The spatial resolution is defined by the diffraction limit and is not enough for single-cell detection. However, several promising techniques, such as THz solid-immersion microscopy, 35,36 can overcome this limit and demonstrate high efficiency in biomedical imaging. The new effective approaches for signal enhancement, contrast and sensitivity improvement, and general signal analysis will be helpful for detection tasks.…”

Section: Resultsmentioning

confidence: 99%

“…TPS might be implemented in reflection or transmission modes, and the imaging is generally achieved by raster-scanning a sample surface with a focused THz beam. [33][34][35][36] At the same time, intensive research has been conducted on THz multipixel cameras and holographic or codedaperture imaging principles. 9,[37][38][39] The main THz spectroscopic approaches that are generally used in biological research are Fourier transform spectroscopy (FTS), photomixing spectrometry, TPS, and TPI.…”

Section: Thz Instrumentationmentioning

confidence: 99%

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Terahertz radiation and the skin: a review

et al. 2021

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Significance: Terahertz (THz) radiation has demonstrated a great potential in biomedical applications over the past three decades, mainly due to its non-invasive and label-free nature. Among all biological specimens, skin tissue is an optimal sample for the application of THz-based methods because it allows for overcoming some intrinsic limitations of the technique, such as a small penetration depth (0.1 to 0.3 mm for the skin, on average). Aim: We summarize the modern research results achieved when THz technology was applied to the skin, considering applications in both imaging/detection and treatment/modulation of the skin constituents. Approach: We perform a review of literature and analyze the recent research achievements in THz applications for skin diagnosis and investigation. Results: The reviewed results demonstrate the possibilities of THz spectroscopy and imaging, both pulsed and continuous, for diagnosis of skin melanoma and non-melanoma cancer, dysplasia, scars, and diabetic condition, mainly based on the analysis of THz optical properties. The possibility of modulating cell activity and treatment of various diseases by THz-wave exposure is shown as well. Conclusions: The rapid development of THz technologies and the obtained research results for skin tissue highlight the potential of THz waves as a research and therapeutic instrument. The perspectives on the use of THz radiation are related to both non-invasive diagnostics and stimulation and control of different processes in a living skin tissue for regeneration and cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Thz Instrumentationmentioning

confidence: 99%

Terahertz radiation and the skin: a review

et al. 2021

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“…IOC technologies are also of potential interest in histopathological diagnosis of tissues, as well as in combination of histopathological characterization and THz microscopy [3] (such as the THz solid immersion microscopy [48,49] ), where unmasking the main histotypic properties of the studied tissues using IOC would allow for more subtle and accurate differentiation between pathologically changed and normal tissues. [50] Finally, IOC technologies can be applied for suppressing an impact of water on the THz response of tissues, thus, revealing nonwater related tissue features.…”

Section: Comparison Of Hyperosmotic Agentsmentioning

confidence: 99%

Optimal hyperosmotic agents for tissue immersion optical clearing in terahertz biophotonics

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Dolganova

Chernomyrdin

et al. 2020

Journal of Biophotonics

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In this work, a thorough analysis of hyperosmotic agents for the immersion optical clearing (IOC) in terahertz (THz) range was performed. It was aimed at the selection of agents for the efficient enhancement of penetration depth of THz waves into biological tissues. Pulsed spectroscopy in the frequency range of 0.1 to 2.5 THz was applied for investigation of the optical properties of common IOC agents. Using the collimated transmission spectroscopy in visible range, binary diffusion coefficients of tissue water and agent in ex vivo rat brain tissue were measured. IOC agents were objectively compared using two-dimensional nomogram, accounting for their THz-wave absorption coefficients and binary diffusion coefficients. The results of this study demonstrate an interplay between the penetration depth enhancement and the diffusion rate and allow for pointing out glycerol as an optimal agent among the considered ones for particular applications in THz biophotonics.

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“…They located cancerous areas in excised human breast tissue samples at 1.89 THz and obtained the absolute refractive index values of the breast cancer. In 2018, Chernomyrdin et al distinguished the connective fibrous tissues from normal tissues of an ex vivo breast using CW THz SI microscopy [54,85]. The working principle of the imaging method has been explored in the Section 2.5.…”

Section: Breast Cancermentioning

confidence: 99%

“…Sci. 2021, 11, x FOR PEER REVIEW 17 of 27 [54,85]. The working principle of the imaging method has been explored in the Section 2.5.…”

Section: Breast Cancermentioning

confidence: 99%

Continuous-Wave THz Imaging for Biomedical Samples

et al. 2020

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In the past few decades, the applications of terahertz (THz) spectroscopy and imaging technology have seen significant developments in the fields of biology, medical diagnosis, food safety, and nondestructive testing. Label-free diagnosis of malignant tumours has been obtained and also achieved significant development in THz biomedical imaging. This review mainly presents the research status and prospects of several common continuous-wave (CW) THz medical imaging systems and applications of THz medical imaging in biological tissues. Here, we first introduce the properties of THz waves and how these properties play a role in biomedical imaging. Then, we analyse both the advantages and disadvantages of the CW THz imaging methods and the progress of these methods in THz biomedical imaging in recent ten years. Finally, we summarise the obstacles in the way of the application of THz bio-imaging application technology in clinical detection, which need to be investigated and overcome in the future.

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Numerical analysis and experimental study of terahertz solid immersion microscopy

Cited by 31 publications

References 92 publications

Terahertz radiation and the skin: a review

Terahertz radiation and the skin: a review

Optimal hyperosmotic agents for tissue immersion optical clearing in terahertz biophotonics

Continuous-Wave THz Imaging for Biomedical Samples

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