Number of positive systematic sextant biopsies predicts surgical margin status at radical prostatectomy

Tigrani, Vida S; Bhargava, Vivek; Shinohara, Katsuto; Presti, Joseph C.

doi:10.1016/s0090-4295(99)00211-3

Cited by 49 publications

(31 citation statements)

References 19 publications

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“…It has been argued that bilateral positive biopsies, increasing numbers of positive cores, the presence of perineural invasion and extended individual core cancer lengths or areas suggest a larger tumour volume with a greater likelihood of adverse pathological findings (25)(26)(27)(28)(29). This study's inclusion of a sizeable cohort of patients diagnosed using TP biopsy reflects the distinctive historical aspect of this patient population, but it is interesting that it demonstrates no significant difference in the description of the pattern of malignancy relating to biopsy technique.…”

Section: Discussionmentioning

confidence: 99%

Can prostate biopsies predict suitability for nerve‐sparing radical prostatectomy?

Connolly

O’Malley

O'Brien

et al. 2004

Scandinavian Journal of Urology and Nephrology

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Section: Discussionmentioning

confidence: 99%

Can prostate biopsies predict suitability for nerve‐sparing radical prostatectomy?

Connolly

O’Malley

O'Brien

et al. 2004

Scandinavian Journal of Urology and Nephrology

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“…The major exception to this is in the prostate gland, as numerous studies have shown that different measures of tumor size/extent on needle biopsy provide clinically important information. 1 In addition to the ability to predict a potentially insignificant disease that could be managed by active surveillance, 2 tumor extent on prostate needle biopsy has been found to correlate well with tumor volume on radical prostatectomy 3-7 and helps predict margin status, 8 extraprostatic extension, 9,10 and, in combination with other parameters, posttreatment tumor progression. [11][12][13][14][15] There are several studies of mammary carcinoma that have examined the relationship between radiologic tumor size and the subsequent size on final excision [16][17][18][19][20][21] as well as those that have evaluated the relationship between radiologic or pathologic tumor size (on excision) and the likelihood of lymph node metastasis.…”

mentioning

confidence: 99%

The Impact of Tumor Size in Breast Needle Biopsy Material on Final Pathologic Size and Tumor Stage

Edwards

Oakley

Koyama

et al. 2013

American Journal of Surgical Pathology

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Tumor size is a significant prognostic indicator for invasive mammary carcinoma. By current standards, this is routinely reported during pathologic evaluation of the definitive excision, but no recommendations exist for reporting tumor size in needle biopsy material. The purpose of this study is to evaluate the relationship between tumor size on breast needle biopsy specimens and that on subsequent definitive excision specimens and to evaluate the impact of the former, if any, in determining the final pathologic tumor stage. This was achieved by an evaluation of 222 consecutive cases of invasive mammary carcinoma for which both the diagnostic biopsy and definitive excision were available for review. Of 200 cases without a history of neoadjuvant therapy, there were 161 (80.5%) cases in which the tumor size on biopsy was smaller, 15 (7.5%) cases in which the sizes were equal, and 24 (12%) in which the size on biopsy was greater, including 6 (3%) cases with no residual tumor on excision. The average size change (excision size minus biopsy size) increased with increasing tumor stage, with these being significantly lower in pT1a compared with pT1b tumors (-0.14 vs. 0.17 mm; P=0.0002), pT1a/b compared with pT1c tumors (0.12 vs. 0.53 mm; P<0.0001), and pT1 compared with pT2/3 tumors (0.32 vs. 2.2 mm; P<0.001). Of the 24 cases in which tumor size on biopsy was greater than that on excision, there were 15 (7.5% of cohort) in which the tumor size on biopsy was the sole determinant of a higher final pathologic T stage. A larger tumor size on biopsy compared with that on excision was significantly associated with a lower final pathologic T stage (P<0.001) but not with patient age, histologic type, histologic grade, mitotic score, or the presence/absence of ductal carcinoma in situ. Evaluation of the remaining 22 cases also showed that there was a clear association between a history of neoadjuvant therapy and the finding of a larger size on biopsy compared with that on excision (P<0.0001). These findings indicate that tumor size on breast needle biopsy is not infrequently larger than that on excision and can also dictate the final pathologic T stage. Accordingly, it is recommended that the greatest extent of invasive carcinoma is reported in all needle biopsy specimens.

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“…[21] studied 108 patients who underwent prostatectomy for prostate cancer and found that the number of positive biopsies was the best predictor of margin status. This is not surprising, as it is known that serum PSA can be higher in simple hyperplasia of the prostate than in cases of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Prediction of extracapsular extension of prostate cancer based on systematic core biopsies

Tarján

Tot

2006

Scandinavian Journal of Urology and Nephrology

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Number of positive systematic sextant biopsies predicts surgical margin status at radical prostatectomy

Cited by 49 publications

References 19 publications

Can prostate biopsies predict suitability for nerve‐sparing radical prostatectomy?

Can prostate biopsies predict suitability for nerve‐sparing radical prostatectomy?

The Impact of Tumor Size in Breast Needle Biopsy Material on Final Pathologic Size and Tumor Stage

Prediction of extracapsular extension of prostate cancer based on systematic core biopsies

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