Number of erythrocytes as a prognostic marker in patients undergoing heart valve surgery

Background: Acute kidney injury (AKI) is one of the serious postoperative complications in patients undergoing heart valve surgery. The aim of the present study was to identify selected biomarkers to predict AKI requiring renal replacement. Methods: A prospective study was conducted on a group of 751 patients undergoing heart valve surgery. The data on risk factors, preoperative complete blood count, course of operations and postoperative period was assessed. The primary endpoint at the 30-day follow-up was postoperative AKI requiring renal replacement therapy. The secondary end-point was death from all causes in patients with postoperative AKI requiring renal replacement. Results: The primary endpoint occurred in 46 patients. At multivariate analysis: age, red cell distribution width (RDW) and C-reactive protein remained independent predictors of the primary endpoint. Hemoglobin and RDW were associated with an increased risk of death. Conclusions: Elevated RDW is associated with a higher risk of postoperative AKI and death in patients with AKI. (Cardiol J XXXX; XX, X: xx-xx)

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“…Funding: Statutory work at the Institute of Cardiology, no 1705. [14,[17][18][19][20][21][22][23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

“…in the course of hemolysis. Previous studies have indicated the predictive ability of RDW in various cardiovascular disorders [14][15][16][17][18][19][20][21][22][23][24]. Identifying risk factors for developing AKI and aggressive early intervention is extremely important to optimize outcomes in patients with heart valve disease.…”

Section: Introductionmentioning

confidence: 99%

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

et al. 2020

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“…12 , 15 , 23 So far, it has been shown that parameters such as RDW, RBC or troponin T can improve the predictive power of commonly known risk calculators. 24 , 26 …”

Section: Discussionmentioning

confidence: 99%

<p>Usefulness of FRAIL Scale in Heart Valve Diseases</p>

Duchnowski¹,

Szymański²,

Kuśmierczyk³

et al. 2020

CIA

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Background The frailty syndrome is a serious health problem for an aging population. The occurrence of frailty in the group of symptomatic patients undergoing heart valve surgery may have additional clinical implications. The predictive ability of the FRAIL scale in patients undergoing heart valve surgery during a 30-day follow-up has not yet been described. Patients and Methods A prospective study was conducted on a group of consecutive patients with hemodynamically significant valve disease (aortic stenosis, aortic regurgitation, mitral stenosis and mitral regurgitation) that underwent elective valve surgery in 2014–2019. The primary endpoint was 30-day mortality. Univariate analysis, followed by multivariate regression analysis, was performed. Results The study group included 672 consecutive patients (aortic valve stenosis, aortic regurgitation, mitral stenosis and mitral regurgitation) who underwent replacement or repair of the valve. Twenty-five patients died during the 30-day follow-up. At multivariate analysis, FRAIL scale result (OR 2.802; 95% CI 1.275–6.157; p=0.01) and red cell distribution width (RDW) (OR 1.810; 95% CI 1.181–2.775; p=0.006) remained independent predictors of the primary endpoint. Conclusion The presented study showed the predictive ability of the FRAIL scale result in patients undergoing heart valve surgery for 30-day mortality.

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“…The available literature suggests that morbidity in patients with elevated inflammatory parameters results from the balance between numerous proinflammatory and anti-inflammatory factors [ 18 ]. In addition, modifiable factors such as diet, physical activity levels, fat content in the body, smoking or genetic background may play an important role [ 19 – 21 ]. In the present study we found that the pre-operative level of CRP is an independent predictor of in-hospital death in patients undergoing heart valve surgery.…”

Section: Discussionmentioning

confidence: 99%

High-sensitivity C-reactive protein as a prognostic marker in patients undergoing valve surgery

Duchnowski

Szymański

Kuśmierczyk

et al. 2020

kitp

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Introduction: An inflammatory reaction is a local or systemic response of the organs or tissues of the body to many damaging factors. One of the exponents of the inflammatory process is C-reactive protein (CRP). Aim: To investigate the prognostic value of C-reactive protein (CRP) in patients undergoing valve surgery. Material and methods: A prospective study was conducted on a group of consecutive patients with haemodynamically significant valve defects who underwent elective valve repair or replacement surgery. The primary end-point was in-hospital death from all causes. Patients were followed by direct observation during hospitalization. The risk of surgery using Euro-SCORE II was calculated for each patient. The plasma levels of C-reactive protein were measured by the Cardiac C-Reactive Protein (Latex) High Sensitive Test (Roche, Germany). Results: The study group included 562 patients. The mean age in the studied population was 63 (standard deviation (SD) ±12). The mean plasma preoperative CRP level was 0.39 ±0.3 mg/dl. The primary endpoint occurred in 25 patients. At multivariate analysis age (p = 0.01), CRP (p = 0.02) and NT-proBNP (p = 0.03) remained independent predictors of the primary endpoint. A significant correlation was found between the level of CRP and haemoglobin (r =-0.3; p < 0.0001), red cell distribution width (r = 0.22; p < 0.0001), ejection fraction (r =-0.24, p = 0.007), troponin T (r = 0.3; p < 0.0001), creatinine (r = 0.26; p = 0.001) and body mass index (r =-0.29; p = 0.005). The average total time of hospitalization after the operation in patients with occurrence of the primary endpoint was 25 ±13 days. Conclusions: Elevated preoperative CRP was associated with a poorer outcome following valve surgery.

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Number of erythrocytes as a prognostic marker in patients undergoing heart valve surgery

Cited by 11 publications

References 12 publications

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

<p>Usefulness of FRAIL Scale in Heart Valve Diseases</p>

High-sensitivity C-reactive protein as a prognostic marker in patients undergoing valve surgery

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