Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

Hypoxia regulates fibrosis-related genes in the placentas of patients with preeclampsia: it credits to histone lactylation?

“…In recent decades, agriculture has started to become dependent on the (synthetic) chemical industry, which produces patented fertilizers, pesticides, and seeds [2,3]. Importantly, there are several adverse health effects associated with exposure to chemical pesticides, including dermatological, gastrointestinal, respiratory, reproductive, endocrine, obstetric (child growth), carcinogenic, and neuropsychiatric consequences [4].…”

“…The effectiveness of this process mainly depended on the fact that the oxamate reduced intracellular lactate levels. Interestingly, as more than one lactylated protein exists in cells, the reduction of intracellular lactate levels under oxamate treatment may inhibit the lactylation of more proteins apart from histone [3]. Therefore, it was unable to effectively distinguish whether the decreased expression of FN1 and SERPINE1 was due to inhibition of histone or other proteins lactylation.…”

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

“…While certain observations endorse the concept that histone Kla is crucial for the proliferation of tumours, alternative studies argue that histone Kla lacks the ability to convert healthy cells into cancerous ones. This suggests that histone Kla plays a role in facilitating the growth of developing tumours rather than initiating tumourigenesis initially 15,20 …”

“…[12][13][14] Significantly, the disturbance of epigenetic alterations and metabolic pathways is frequently linked to various illnesses, and the interaction between metabolism and chromatin presents numerous prospects for therapeutic interventions. 15,16 Recognising the interaction between metabolic remodelling and dynamic histone tuning is of utmost importance as it is currently in its early stages. The purpose of this review is to combine current information on the influence of lactate and histone modification on tumour and related gene regulation.…”

Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors

“…[5] NUMB and its mammalian homolog NUMBLIKE (NUMBL) belong to an evolutionarily conserved family of proteins, implicated in a variety range of important cellular processes, including cell fate determination, cell adhesion, cell migration, protein endocytosis and ubiquitination. [6][7][8][9][10][11] In mammals neurogenesis, NUMBL primarily has redundant functions with NUMB. [12] However, NUMB, identified initially as the cell fate determinant, shows asymmetric distribution in cells, yet, NUMBL exhibits to be symmetrically distributed in cytoplasm.…”