Nulliparous and primiparous cows produce less fertile female offspring with lesser concentration of anti-Müllerian hormone (AMH) as compared with multiparous cows

Akbarinejad, Vahid; Gharagozlou, Faramarz; Vojgani, M.; Amirabadi, M.M. Bagheri

doi:10.1016/j.anireprosci.2018.08.032

Cited by 29 publications

(15 citation statements)

References 52 publications

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“…This finding is in accordance with evidence from our previous study conducted on Irish Holstein Friesian cattle in a pasture-based system, where daughters of heifers had on average 3 follicles less than daughters of lactating dams (Walsh et al, 2014). Similarly, AMH concentrations were greater in Holstein heifers born to multiparous cows compared with nulliparous heifers (Akbarinejad et al, 2018), and beef heifers born to cows had more antral follicles than herd mates born to cows (McNeel et al, 2017). The repeatability of this finding across independent studies conducted in different countries and farming conditions is remarkable; Different superscripted letters within the same row indicate statistical differences (P < 0.05).…”

Section: Discussionsupporting

confidence: 92%

Exposure of dairy cows to high environmental temperatures and their lactation status impairs establishment of the ovarian reserve in their offspring

Succu

Sale²,

Ghirello

et al. 2020

Journal of Dairy Science

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The objectives of this study were to establish if exposure of pregnant dairy cows to high environmental temperatures and humidity during the first trimester of pregnancy impairs the establishment of the ovarian reserve (total number of healthy follicles and oocytes in ovaries) and fertility in their offspring. Serum anti-Müllerian hormone (AMH) concentrations and number of follicles ≥3 mm (antral follicle count; AFC) were assessed on a random day of the estrous cycle in 310 sixteen-month-old dairy heifers. Based on season of their conception and early fetal life, heifers were separated into 2 groups: summer (mean monthly temperature-humidity index = 69.33 ± 2.6) and winter (temperature-humidity index = 54.91 ± 1.08). The AMH and AFC were lower in summer (419.27 ± 22.81 pg/mL and 9.32 ± 0.42 follicles, respectively) compared with winter heifers (634.91 ± 47.60 pg/mL and 11.84 ± 0.46 follicles, respectively) and were not influenced by farm and age at sampling. Heifers born to dams that were not being milked during gestation had lower AMH and AFC compared with offspring of cows on their first lactation, whereas no difference was detected between offspring of cows on their first and subsequent lactations. Summer and winter heifers had similar age at first service and at first calving, and similar number of services per conception. Regardless of season in early fetal life, heifers were classified into 3 groups based on AMH and AFC (low = 20%, intermediate = 60%, high = 20%). Heifers with the lowest AMH were older at first service compared with herd mates with intermediate AMH, but age at first calving and number of services per conception were similar among AMH categories. No difference was detected in any of the fertility measures among AFC categories. Heifers born to mothers exposed to high environmental temperatures in early gestation had smaller ovarian reserves compared with herd mates conceived in winter, but no association between season of early fetal life and fertility at first conception was established. Season of conception and maternal lactation status affect the size of the ovarian reserve, but not fertility, at first conception in the progeny.

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Section: Discussionsupporting

confidence: 92%

Exposure of dairy cows to high environmental temperatures and their lactation status impairs establishment of the ovarian reserve in their offspring

Succu

Sale²,

Ghirello

et al. 2020

Journal of Dairy Science

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“…This result explains the decrease in the ovarian reservoir of follicles with increase the age in the doe as a result of the decrease in the level of AMH in the serum, which is considered an indicator for knowing the ovarian reservoir from the follicles and determining the productive age of the ovaries related to the association of AMH with age or parity seems contradictory in cattle [18] and compatible with [17] reported there were greater conception rates in primiparous than multiparous heifers and similar fertility. While with the study of [19] there was not any significant correlation between AMH and parity, in other studies concentrations of AMH in second and third lactation cattle were greater than in cows with their first and fourth or more lactations [5] . Nevertheless, AMH concentration has been reported to decrease with age in humans [20] and mice [21] .…”

Section: Resultsmentioning

confidence: 58%

Evaluation of Ovarian Reserve by Using AMH Test before Collection the Oocytes for ICSI Technique

Khamees,

Hatif

2021

MLU

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This study was conducted on goats with the purpose to evaluate the ovarian reserve before females submit to the ova retrieval for intracytoplasmic sperm injection (ICSI). The study was conducted at the college of veterinary medicine -the University of Baghdad and Middle East Labs -Baghdad (2019-2020. The study included thirty female goats (does) within the age of puberty and sexual maturity. The animals were divided into two groups: group I (˂ 4 years old), and group II (> 4 years old). A blood sample (6 ml) was collected from each animal through the jugular vein (before slaughter) in tubes containing anticoagulants and then sent to the laboratory for estimation of antimullerian hormone (AMH). The study showed significant increases in the level of AMH (4.02 ± 0.17) of the group I (˂ 4 years old) comparative with (2.22 ± 0.54) to the group II (> 4 years old) at the (<0.01), and this result relation with the number of oocytes obtained from ovarian samples of animals after slaughtering, it was found that the number and quality of oocytes increased in the group I (29 oocytes from a 15ovarian samples , compared with group II (16 oocytes from 15ovarian samples. This result explains the decrease in the ovarian reservoir of follicles with an increase in the age in the doe as a result of the decrease in the level of AMH in the serum, which is considered an indicator for knowing the ovarian reservoir from the follicles and determining the productive age of the ovaries. According to the results of this study, the decrease in the level of AMH in the serum is an indication of a decrease in the number of follicles on the surface of the ovaries, which negatively affects the fertility and productivity of the goats or may affect the fertilization rate and the number of fertilized embryos. The AMH test is considered one of the important tests that must be taken before oocyte collection to reduce the effort and costs involved in conducting any assisted reproduction technique that requires collecting the oocytes from the donor.

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“…Maternal age and parity at first calving therefore have a significant effect on calf BTW. Holstein heifers produced by nulliparous (NP) or primiparous (PP) dams are consistently lighter in comparison with multiparous (MP) offspring [ 40 , 41 , 42 ]. In addition, calves born to Holstein heifers of <22 months of age had a BTW on average 2.75 kg less than those calving at over 22.5 months [ 43 ].…”

Section: Fetal Origins Of Adult Diseasementioning

confidence: 99%

“…This found that the offspring of both the youngest and oldest dams needed more S/C than those from dams in parities 2–5 (parity 1, 1.6 ± 0.10 S/C ( n = 111); parities 2–3, 1.3 ± 0.05 S/C ( n = 223); parities 4–5, 1.2 ± 0.06 S/C ( n = 99), parity > 5, 1.5 ± 0.12 S/C ( n = 60), p = 0.005) (J. S. Brickell and D. C. Wathes, unpublished observations). A retrospective study by Akbarinejad et al [ 42 ] reported that offspring of MP cows were significantly more fertile than those of NP heifers with respect to days to first service, first service conception rate, S/C and calving to conception intervals. The values for the PP offspring were intermediate with, for example, average calving to conception intervals of 142, 136 and 127 days for the NP, PP and MP offspring, respectively.…”

Section: Follow-up Studies Investigating Fetal Programming and Fertilitymentioning

confidence: 99%

Developmental Programming of Fertility in Cattle—Is It a Cause for Concern?

Wathes

2022

Animals

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Cattle fertility remains sub-optimal despite recent improvements in genetic selection. The extent to which an individual heifer fulfils her genetic potential can be influenced by fetal programming during pregnancy. This paper reviews the evidence that a dam’s age, milk yield, health, nutrition and environment during pregnancy may programme permanent structural and physiological modifications in the fetus. These can alter the morphology and body composition of the calf, postnatal growth rates, organ structure, metabolic function, endocrine function and immunity. Potentially important organs which can be affected include the ovaries, liver, pancreas, lungs, spleen and thymus. Insulin/glucose homeostasis, the somatotropic axis and the hypothalamo-pituitary-adrenal axis can all be permanently reprogrammed by the pre-natal environment. These changes may act directly at the level of the ovary to influence fertility, but most actions are indirect. For example, calf health, the timing of puberty, the age and body structure at first calving, and the ability to balance milk production with metabolic health and fertility after calving can all have an impact on reproductive potential. Definitive experiments to quantify the extent to which any of these effects do alter fertility are particularly challenging in cattle, as individual animals and their management are both very variable and lifetime fertility takes many years to assess. Nevertheless, the evidence is compelling that the fertility of some animals is compromised by events happening before they are born. Calf phenotype at birth and their conception data as a nulliparous heifer should therefore both be assessed to avoid such animals being used as herd replacements.

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Nulliparous and primiparous cows produce less fertile female offspring with lesser concentration of anti-Müllerian hormone (AMH) as compared with multiparous cows

Cited by 29 publications

References 52 publications

Exposure of dairy cows to high environmental temperatures and their lactation status impairs establishment of the ovarian reserve in their offspring

Exposure of dairy cows to high environmental temperatures and their lactation status impairs establishment of the ovarian reserve in their offspring

Evaluation of Ovarian Reserve by Using AMH Test before Collection the Oocytes for ICSI Technique

Developmental Programming of Fertility in Cattle—Is It a Cause for Concern?

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