Nulliparity is associated with subtle adverse metabolic outcomes in overweight/obese mothers and their offspring

Seneviratne, Sumudu Nimali; Derraik, José G. B.; Jiang, Yannan; McCowan, Lesley; Gusso, Silmara; Biggs, Janene B.; Parry, David; Cutfield, Wayne S.; Hofman, Paul L.

doi:10.1111/cen.13426

Cited by 6 publications

(7 citation statements)

References 33 publications

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“…The remaining 83 studies were further evaluated based on full text, and 51 articles were excluded for wrong publication type ( n = 26) (i.e., systematic review, study protocol, cohort characteristics report, conference presentation, book), wrong study design ( n = 7), and wrong outcome ( n = 23) (i.e., ineligible infant measurements); 32 articles were included for evaluation. Of these, 13 were randomized controlled trials [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], 16 were single-arm cohort studies [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], and 3 were case-control studies [ 5 , 6 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…The overall risk of bias for randomized controlled trials was low to- moderate. Approximately 54% of the studies (7 of 13) were rated as having “some concerns” for the overall potential risk of bias [ 21 , 22 , 24 , 25 , 27 , 28 , 29 ] ( Figure 2 ). This rating was primarily due to the seven studies being rated as having “some concerns” in the performance risk of bias domain, which was assessed by rating deviations from the intended intervention.…”

Section: Resultsmentioning

confidence: 99%

“… Randomized controlled trial risk of bias summary. Baraket, 2009 [ 17 ], Bisson, 2015 [ 18 ], Clapp, 2000 [ 19 ], Clapp, 2002 [ 20 ], Clark, 2019 [ 21 ], Garnaes, 2017 [ 22 ], Hopkins, 2010 [ 24 ], Seneviratne, 2015 [ 25 ], Seneviratne, 2017 [ 26 ], Sklempe-Kokic, 2018 [ 27 ], Trak-Fellermeie, 2019 [ 28 ], Van Poppel, 2019 [ 29 ], Hoffman, 2019 [ 23 ]. …”

Section: Figurementioning

confidence: 99%

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Physical Activity during Pregnancy and Newborn Body Composition: A Systematic Review

Menke

Duchette

Tinius

et al. 2022

IJERPH

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The current literature demonstrates that not only is exercise during pregnancy safe, but it has substantial maternal and infant benefits and appears to influence infant growth/size throughout pregnancy and at birth. However, many existing studies have investigated only the effects of prenatal exercise on birth weight. The purpose of this review was to determine the impact or association of maternal physical activity during pregnancy on neonatal body composition assessed between birth and two weeks of age. Electronic database searches were conducted on 29 July 2019 for randomized control trials and cohort studies, with an updated search completed on 8 January 2021. A total of 32 articles that met eligibility criteria were selected for review. Overall, prenatal exercise was not associated with infant body composition at birth. Yet, five of the studies identified suggest that infant body composition could be influenced by higher volumes of mid-to-late term prenatal physical activity. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in PROSPERO (Registration No. CRD42020160138).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Physical Activity during Pregnancy and Newborn Body Composition: A Systematic Review

Menke

Duchette

Tinius

et al. 2022

IJERPH

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“…However, the underlying mechanism remains unexplained and requires further exploration. Seneviratne et al [12] have recently reported that nulliparous and multiparous women may confer subtle metabolic disadvantage in overweight and obese mothers and their offspring. In our study, nulliparous women and women with two live birth may have similar magnitude of association with CKD, although the associations were not statistical significant.…”

Section: Discussionmentioning

confidence: 99%

Parity is associated with albuminuria and chronic kidney disease: a population-based study

Sun

Lin

Feng

et al. 2019

Aging

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Background and aims: Epidemiological studies have shown that increasing parity is associated with risk of hypertension and diabetes in parous women. However, the relationship between the parity degree with chronic kidney disease (CKD) is still unknown.Results: Parous women with higher parity had increased age, body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, fasting insulin and decreased high-density lipoprotein cholesterol, eGFR and education levels. Compared with women with one-child birth, those with more than two-child births had greater prevalence of increased urinary albumin excretion (odds ratios [ORs] 1.53, 95% confidence intervals [CI], 1.03 - 2.28) and CKD (ORs 1.79, 95% CI, 1.24 - 2.58) after multiple adjustments. In dose-response analysis, a nonlinear relationship of parity degree with albuminuria and CKD was detected.Conclusion: Parity is associated with higher prevalence of albuminuria and CKD in middle-aged and elderly Chinese women.Methods: We conducted a community-based study in 6,946 women to investigate the association of parity with albuminuria and CKD. Increased urinary albumin excretion was defined as albumin-to-creatinine ratio (ACR) greater or equal than 30 mg/g. CKD was defined as estimated glomerular filtration rate (eGFR) less than 60 mL/min per 1.73 m² or presence of albuminuria.

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“…During fetal development, the hypothalamic-pituitary-adrenal axis is extremely susceptible to programming, and alterations in the expression and function of glucocorticoid receptors and major glucocorticoid regulatory enzymes are observed in those exposed to undernourishment in early life[ 54 ]. Other factors associated with fetal programming include maternal exposure to endocrine disruptors, maternal infection and smoking and nulliparity[ 17 , 55 ]. Nulliparity is potentially associated with subtle adverse metabolic outcomes in overweight/obese mothers and their offspring, through uterine constraint effects[ 55 ].…”

Section: Factors Predisposing To Developmental Programming Of Obesity...mentioning

confidence: 99%

Fetal programming of obesity and type 2 diabetes

Seneviratne

Rajindrajith

2022

WJD

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The prevalence of obesity and type 2 diabetes mellitus has increased rapidly over the past few decades, and prevention efforts have not been successful. Fetal programming involves the earliest stage of obesity development, and provides a novel concept to complement other strategies for lifelong prevention of obesity and type 2 diabetes mellitus. The World Health Organization now advocates a life-course approach to prevent/control obesity, starting with pre-conceptional and antenatal maternal health. Maternal overnutrition, gestational diabetes mellitus and excessive gestational weight gain lead to fetal overgrowth, and “programs” the offspring with an increased risk of obesity and type 2 diabetes mellitus in childhood and adulthood. This review summarizes current data on fetal programming of obesity and type 2 diabetes mellitus including potential causative factors, mechanisms and interventions to reduce its impact.

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Nulliparity is associated with subtle adverse metabolic outcomes in overweight/obese mothers and their offspring

Abstract: Infants born of nulliparous overweight and obese women appear to be exposed to a less favourable metabolic environment in utero, with evidence of subtle adverse metabolic outcomes at birth compared to infants of overweight/obese multiparous women.

Cited by 6 publications

References 33 publications

Physical Activity during Pregnancy and Newborn Body Composition: A Systematic Review

Physical Activity during Pregnancy and Newborn Body Composition: A Systematic Review

Parity is associated with albuminuria and chronic kidney disease: a population-based study

Fetal programming of obesity and type 2 diabetes

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