Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial

Tabak, Benjamin A.; Teed, Adam R.; Castle, Elizabeth; Dutcher, Janine M.; Meyer, Meghan L.; Bryan, Ronnie; Irwin, Michael R.; Lieberman, Matthew D.; Eisenberger, Naomi I.

doi:10.1016/j.psyneuen.2019.04.019

Cited by 37 publications

(29 citation statements)

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“…The great majority of studies emphasize positive, prosocial behavioral outcomes after exogenous oxytocin administration; however, it is important to emphasize that not all studies describe these effects (Keech et al, 2018 ; Tabak et al, 2019 ; Erdozain and Peñagarikano, 2020 ) and some antisocial outcomes have been reported, including increased competitive and aggressive tendencies, particularly in males (Fischer-Shofty et al, 2012 ; Alcorn et al, 2015 ; Ne’eman et al, 2016 ; de Jong and Neumann, 2018 ; Gedeon et al, 2019 ). Others have also reported differential effects of exogenous oxytocin on women compared to men (e.g., Rilling et al, 2012 , 2018 ; Preckel et al, 2014 ; Feng et al, 2015 ; Chen et al, 2016 ; Bredewold and Veenema, 2018 ; Bartz et al, 2019 ; Xu et al, 2020 ).…”

Section: Oxytocin In Humansmentioning

confidence: 99%

“…AVP is also thought to influence human behavior in many ways (Neumann and Landgraf, 2012 ; Benarroch, 2013 ) although significant effects are not always evident (Tabak et al, 2019 ). AVP and oxytocin may interact with each other to influence prosocial vs. antisocial behaviors, trust vs. aggression, fear and so on (Huber et al, 2005 ; Veenema and Neumann, 2018 ; Ebstein et al, 2012 ; Rilling et al, 2012 ; Jurek and Neumann, 2018 ; Song and Albers, 2018 ; Berends et al, 2019 ), at least some of which are sexually dimorphic (Rilling et al, 2014 ; Feng et al, 2015 ; Bredewold and Veenema, 2018 ).…”

Section: The Links Between Oxytocin and Musicmentioning

confidence: 99%

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Links Between the Neurobiology of Oxytocin and Human Musicality

Harvey

2020

Front. Hum. Neurosci.

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The human species possesses two complementary, yet distinct, universal communication systems—language and music. Functional imaging studies have revealed that some core elements of these two systems are processed in closely related brain regions, but there are also clear differences in brain circuitry that likely underlie differences in functionality. Music affects many aspects of human behavior, especially in encouraging prosocial interactions and promoting trust and cooperation within groups of culturally compatible but not necessarily genetically related individuals. Music, presumably via its impact on the limbic system, is also rewarding and motivating, and music can facilitate aspects of learning and memory. In this review these special characteristics of music are considered in light of recent research on the neuroscience of the peptide oxytocin, a hormone that has both peripheral and central actions, that plays a role in many complex human behaviors, and whose expression has recently been reported to be affected by music-related activities. I will first briefly discuss what is currently known about the peptide’s physiological actions on neurons and its interactions with other neuromodulator systems, then summarize recent advances in our knowledge of the distribution of oxytocin and its receptor (OXTR) in the human brain. Next, the complex links between oxytocin and various social behaviors in humans are considered. First, how endogenous oxytocin levels relate to individual personality traits, and then how exogenous, intranasal application of oxytocin affects behaviors such as trust, empathy, reciprocity, group conformity, anxiety, and overall social decision making under different environmental conditions. It is argued that many of these characteristics of oxytocin biology closely mirror the diverse effects that music has on human cognition and emotion, providing a link to the important role music has played throughout human evolutionary history and helping to explain why music remains a special prosocial human asset. Finally, it is suggested that there is a potential synergy in combining oxytocin- and music-based strategies to improve general health and aid in the treatment of various neurological dysfunctions.

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Section: Oxytocin In Humansmentioning

confidence: 99%

Section: The Links Between Oxytocin and Musicmentioning

confidence: 99%

Links Between the Neurobiology of Oxytocin and Human Musicality

Harvey

2020

Front. Hum. Neurosci.

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“…We limited this analysis to EMG responses to happy faces, as our task failed to elicit mimicry of anger. Given that there is no clear theoretical boundary for oxytocin's social-cognitive effects for setting the equivalence bounds (Quintana, 2018), we defined the smallest effect size of interest-based on the smallest effect size detectable with 80% power given our sample size (Quintana, 2018;Tabak et al, 2019). The alpha level was set to 0.05.…”

Section: Equivalence Testingmentioning

confidence: 99%

The Influence of Reward on Facial Mimicry: No Evidence for a Significant Effect of Oxytocin

Trilla

Drimalla

Bajbouj

et al. 2020

Front. Behav. Neurosci.

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Recent findings suggest a role of oxytocin on the tendency to spontaneously mimic the emotional facial expressions of others. Oxytocin-related increases of facial mimicry, however, seem to be dependent on contextual factors. Given previous literature showing that people preferentially mimic emotional expressions of individuals associated with high (vs. low) rewards, we examined whether the reward value of the mimicked agent is one factor influencing the oxytocin effects on facial mimicry. To test this hypothesis, 60 male adults received 24 IU of either intranasal oxytocin or placebo in a double-blind, between-subject experiment. Next, the value of male neutral faces was manipulated using an associative learning task with monetary rewards. After the reward associations were learned, participants watched videos of the same faces displaying happy and angry expressions. Facial reactions to the emotional expressions were measured with electromyography. We found that participants judged as more pleasant the face identities associated with high reward values than with low reward values. However, happy expressions by low rewarding faces were more spontaneously mimicked than high rewarding faces. Contrary to our expectations, we did not find a significant direct effect of intranasal oxytocin on facial mimicry, nor on the reward-driven modulation of mimicry. Our results support the notion that mimicry is a complex process that depends on contextual factors, but failed to provide conclusive evidence of a role of oxytocin on the modulation of facial mimicry.

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“…Avpr1a encodes a receptor for arginine vasopressin, which is a neurohypophysial hormone involved in the regulation of adrenocorticotropic hormone released from the pituitary 44 . A recent study has shown that the blocking AVPR1A may improve social communication in autism spectrum disorder 45 . Chat encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine.…”

Section: Hypothalamus Datamentioning

confidence: 99%

Statistical Analysis of Spatial Expression Pattern for Spatially Resolved Transcriptomic Studies

Sun

Zhu

Zhou

2019

Preprint

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Recent development of various spatially resolved transcriptomic techniques has enabled gene expression profiling on complex tissues with spatial localization information. Identifying genes that display spatial expression pattern in these studies is an important first step towards characterizing the spatial transcriptomic landscape. Detecting spatially expressed genes requires the development of statistical methods that can properly model spatial count data, provide effective type I error control, have sufficient statistical power, and are computationally efficient. Here, we developed such a method, SPARK. SPARK directly models count data generated from various spatial resolved transcriptomic techniques through generalized linear spatial models. With a new efficient penalized quasilikelihood based algorithm, SPARK is scalable to data sets with tens of thousands of genes measured on tens of thousands of samples. Importantly, SPARK relies on newly developed statistical formulas for hypothesis testing, producing well-calibrated p-values and yielding high statistical power. We illustrate the benefits of SPARK through extensive simulations and in-depth analysis of four published spatially resolved transcriptomic data sets. In the real data applications, SPARK is up to ten times more powerful than existing approaches. The high power of SPARK allows us to identify new genes and pathways that reveal new biology in the data that otherwise cannot be revealed by existing approaches.

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Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial

Cited by 37 publications

References 37 publications

Links Between the Neurobiology of Oxytocin and Human Musicality

Links Between the Neurobiology of Oxytocin and Human Musicality

The Influence of Reward on Facial Mimicry: No Evidence for a Significant Effect of Oxytocin

Statistical Analysis of Spatial Expression Pattern for Spatially Resolved Transcriptomic Studies

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