NUIG4: A biocompatible pcu metal–organic framework with an exceptional doxorubicin encapsulation capacity

Ahmed, Ahmed; Efthymiou, Constantinos G.; Sanii, Rana; Patyk‐Kaźmierczak, Ewa; Alsharabasy, Amir M.; Winterlich, Meghan; Kumar, Naveen; Tong, Wenming; Guerin, Sarah; Farràs, Pau; Hudson, Sarah P.; Thompson, Damien; Zaworotko, Michael J.; Tasiopoulos, Anastasios J.; Papatriantafyllopoulou, Constantina

doi:10.1039/d1tb02176a

Cited by 5 publications

(7 citation statements)

References 88 publications

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“…Certain topologies are more prone to the formation of highly interpenetrated nets. Specifically, MOF topologies with low linker and SBU connectivity such as pcu and dia are more prone to interpenetration than those with high connectivity [ 149 , 150 , 151 , 152 , 153 , 154 ]. MOFs with srs topology with up to 54-fold interpenetrated nets have been reported [ 155 ].…”

Section: Synthesismentioning

confidence: 99%

Synthesis and Biomedical Applications of Highly Porous Metal–Organic Frameworks

Ahmed

McHugh

Papatriantafyllopoulou

2022

Molecules

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In this review, aspects of the synthesis, framework topologies, and biomedical applications of highly porous metal–organic frameworks are discussed. The term “highly porous metal–organic frameworks” (HPMOFs) is used to denote MOFs with a surface area larger than 4000 m2 g−1. Such compounds are suitable for the encapsulation of a variety of large guest molecules, ranging from organic dyes to drugs and proteins, and hence they can address major contemporary challenges in the environmental and biomedical field. Numerous synthetic approaches towards HPMOFs have been developed and discussed herein. Attempts are made to categorise the most successful synthetic strategies; however, these are often not independent from each other, and a combination of different parameters is required to be thoroughly considered for the synthesis of stable HPMOFs. The majority of the HPMOFs in this review are of special interest not only because of their high porosity and fascinating structures, but also due to their capability to encapsulate and deliver drugs, proteins, enzymes, genes, or cells; hence, they are excellent candidates in biomedical applications that involve drug delivery, enzyme immobilisation, gene targeting, etc. The encapsulation strategies are described, and the MOFs are categorised according to the type of biomolecule they are able to encapsulate. The research field of HPMOFs has witnessed tremendous development recently. Their intriguing features and potential applications attract researchers’ interest and promise an auspicious future for this class of highly porous materials.

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Section: Synthesismentioning

confidence: 99%

Synthesis and Biomedical Applications of Highly Porous Metal–Organic Frameworks

Ahmed

McHugh

Papatriantafyllopoulou

2022

Molecules

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“…They have also been rapidly developed in different drug delivery systems as new drug carriers, giving a broad range of prospects. MOFs have the advantages of large specific surface area and adjustable pore size, enabling them to have strong adsorption capacity for drug molecules, so the combination of MOF and drug can enhance the loading of drugs to a certain extent 16–19 . In addition, when used as drug carrier materials, MOFs can also improve the stability and bioavailability of drugs.…”

Section: Introductionmentioning

confidence: 99%

“…MOFs have the advantages of large specific surface area and adjustable pore size, enabling them to have strong adsorption capacity for drug molecules, so the combination of MOF and drug can enhance the loading of drugs to a certain extent. [16][17][18][19] In addition, when used as drug carrier materials, MOFs can also improve the stability and bioavailability of drugs. For example, when MOF is combined with antitumor drugs, such as paclitaxel and doxorubicin, it significantly improves the stability of the drug in organisms.…”

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confidence: 99%

GCMC simulations to study the potential of MOFs as drug delivery vehicles

Zhu

et al. 2023

Applied Organom Chemis

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Porous polymer metal–organic frameworks (MOFs), having the characteristics of large specific surface area, high porosity, and large drug load, are used in the field of medicine. In order to explore the feasibility of MOFs to load drugs, we have made an attempt to analyze the drug loading of MOFs at the molecular level. In order to provide sufficient theoretical support for realistic research, especially in terms of adsorption sites and the adsorption capacity, we selected five MOFs, UiO‐66, UiO‐66‐NH2, UiO‐66‐COOH, UiO‐67, and UiO‐66‐NDC, with bendamustine and 5‐Fluorouracil (5‐FU) as model drugs, and applied Grand Canonical Monte Carlo (GCMC) simulation to calculate the interaction between carrier MOFs and drug molecules, adsorption sites, isothermal adsorption lines and drug loads, and compared them with real experiments. The results showed all five MOFs to have strong interaction with drug molecules, and MOFs after adsorbing drug molecules were thermally stable. The best adsorption effect on bendamustine was found to be of UiO‐66‐COOH, with a drug loading capacity of 20.94 ± 0.99%. The best adsorption effect on 5‐FU was of UiO‐66‐NDC, with a drug loading capacity of 51.23 ± 1.09%. It has been further proven that MOFs have the potential to participate in oral administration as drug carriers, and have broad prospects in the field of biomedical applications.

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“…5,[17][18][19] MOFs have expanded the range of applications of CPs to include gas storage, gas separation, imaging, energy storage and conversion, optics, heterogeneous catalysis, and other fields. [3][4][5]20,21 The discovery of MOFs in 1995 was a significant milestone in the field of CPs and materials chemistry; however, the use of 1D chains in applications remains of special interest because they can offer advantages compared to their framework analogues. This is merely due to their simple topology 8 and repeating unit diversity, while their relatively high solubility facilitates their processability in industrial applications and manufacturing.…”

Section: Introductionmentioning

confidence: 99%