Nucleus pulposus tissue engineering: a brief review

Yang, Xinlin; Li, Xudong

doi:10.1007/s00586-009-1092-8

Cited by 109 publications

(89 citation statements)

References 65 publications

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“…Tissue engineering approaches often combine growth factors and cells to attempt to repair the nucleus pulposus; however, in the harsh catabolic environment of the degenerating disc, growth factors and cells cannot survive [15][16][17][18][19][20]. The addition of a biomaterial carrier has the potential to increase cell viability and enable long-term growth factor delivery.…”

Section: Introductionmentioning

confidence: 99%

Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering

et al. 2017

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Background Context: Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus. Intact CSPGs are critical to water retention and maintenance of the nucleus osmotic pressure. Decellularization of healthy nucleus pulposus tissue has the potential to serve as an ideal matrix for tissue engineering of the disc because of the presence of native disc proteins and CSPGs. Injectable in situ gelling matrices are the most viable therapeutic option to prevent damage to the anulus fibrosus and future disc degeneration.

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Section: Introductionmentioning

confidence: 99%

Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering

et al. 2017

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“…Symptomatic disc degeneration, on the other hand, is associated with various spinal diseases that can reduce the quality of life. 3,4 The decrease in the water content of the gelatinous nucleus pulposus with aging reduces the ability of the intervertebral disc to distribute axial forces. This vicious cycle results in progressive fibrosis, as well as in changes in the collagen composition of both the annulus fibrosus and nucleus pulposus, and disc degeneration occurs.…”

mentioning

confidence: 99%

Migration of fragments into the spinal canal after intervertebral polyethylene glycol implantation: an extremely rare adverse effect

Akgun

Öztürk²,

Çakın³

et al. 2014

SPI

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Percutaneous intervertebral hydrogel (polyethylene glycol) implantation is a current treatment procedure that aims to restore hydration of a degenerated disc. There have been a few studies that claim that polyethylene glycol is successful for pain relief as the intervertebral space restores its hydration and elasticity. This procedure is reported to be indicated for discogenic low-back pain and mild radicular pain as it contributes to disc restoration. In this report, the authors describe the case of a 43-year-old woman who was admitted with low-back and right leg pain. Muscle strength in dorsiflexion of the right ankle and right toe was 3/5. The patient had undergone hydrogel implantation for L4–5 intervertebral disc restoration 2 days prior to presentation. There was a significant increase in the patient's complaints after hydrogel implantation, and acute weakness in the right ankle and toe had developed. Magnetic resonance imaging of the lumbar vertebrae, which was performed before the hydrogel implantation, showed a significant narrowing of the L4–5 disc space height, and a disc herniation that extended to the right neural foramen and caused compression of the dural sac. The patient underwent surgery immediately. The sequestered disc fragment that caused a prominent stenosis in the spinal canal, as well as hydrogel fragments, was removed. There was an improvement in the patient's complaints and motor deficit postoperatively. In this paper, a very rare complication is reported. In patients who have increased pain after intervertebral hydrogel implantation and who develop a neurological deficit, the migration of the applied material into the spinal canal should be considered.

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“…Biomaterials have also been used as cell carriers and release systems for active factors in order to achieve regeneration. Resident cells in the native IVD can migrate into hydrogels, providing a framework for regeneration by native cells (Anderson et al, 2005;Yang and Li, 2009). The focus of this review is to explore the applicability of various biomaterials in IVD regeneration, with a focus on the NP and AF and on biodegradable biomaterials, as biostable materials (materials that do not degrade) are often implants and prostheses rather than elements contributing to regeneration of the IVD.…”

Section: Regenerative Medicine (Rm) As Emerging Approach For Ivd Degementioning

confidence: 99%

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.

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Nucleus pulposus tissue engineering: a brief review

Cited by 109 publications

References 65 publications

Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering

Creation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering

Migration of fragments into the spinal canal after intervertebral polyethylene glycol implantation: an extremely rare adverse effect

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

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