Nucleus lentiformis – A new model for psychiatry?

Sperling, Wolfgang; Müller, Helge

doi:10.1016/j.mehy.2011.02.005

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…OG worked as a key node in motor inhibition network, which could inhibit the response to incongruous stimulation (Hardee et al, 2014 ). LN moderates reward and value-based decision making (Sperling and Müller, 2011 ). Moreover, PCUN and IFL are needed to initiate preferential allocation of attentional resources in preparation for actions elicited by craving (Folstein et al, 1975 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study

Sheng

Wang

et al. 2022

Front. Aging Neurosci.

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BackgroundPrevious neuroimaging studies reported inconsistent results for comparison between Parkinson's disease (PD) with impulse control disorder (PD-ICD) and without ICD (PD-no ICD).MethodsA search was performed in databases (PubMed and Web of Science) to identify studies published before May 2022. An anatomic likelihood estimation (ALE) method study was made for neuroimaging studies in PD-ICD.ResultsThe study included 20 studies (including 341 PD-ICD and 437 PD-no ICD). PD-ICD patients showed significant cortical thinning in the right inferior frontal gyrus (IFG), the right middle frontal gyrus (MFG), the left superior frontal gyrus (SFG), the right precentral gyrus (PCG) and the left cingulate gyrus (CG), compared to PD-no ICD patients. The ALE study showed reduced resting-state brain activation in the right IFG, the right PCG, the left insula and the right transverse temporal gyrus (TTG) in PD-ICD, compared to PD-no ICD patients. In addition, PD-ICD showed increased resting-state brain activation in the right caudate, the bilateral insula and the left orbital gyrus (OG), compared to PD-no ICD patients. The study indicated reduced task-related brain activation in the right caudate, the right MFG, the right lentiform nucleus (LN) and the right precuneus (PCUN) in PD-ICD, compared to PD-no ICD patients. The study showed increased task-related brain activation in the left inferior parietal lobule (IPL), the right medial frontal gyrus, the right caudate and the right PCG in PD-ICD, compared to PD-no ICD patients.ConclusionsThe present ALE analysis has confirmed that brain changes in frontal, temporal and basal ganglia regions are among the most frequently reported regions in PD-ICD. Deficits in these regions could play a role in diagnosis of PD-ICD.

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Section: Discussionmentioning

confidence: 99%

Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study

Sheng

Wang

et al. 2022

Front. Aging Neurosci.

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“…The nucleus lentiformis plays the role of a pacemaker for the mesolimbic and cortical regions, which are mainly responsible for motoric coordination. On the other hand, researchers are attracted to the question as to the extent to which the nucleus lentiformis has a mediating or moderating function in emotional, cognitive, and behavioral regulation (29). Nucleus lentiformis represents a large portion of the basal ganglia including the putamen and globus pallidus and specific structures within this broad area are known to be important for reward and value‐based decision making, including the ventral striatum/nucleus accumbens and ventral pallidum (3,5).…”

Section: Discussionmentioning

confidence: 99%

Sexual Behavioral Disinhibition Associated with Nucleus Lentiformis Lesion: A Forensic Neuroscience Perspective Through a Case

Balcıoğlu

Doğan

Incı

et al. 2020

Journal of Forensic Sciences

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Organic brain disturbances particularly related to frontal cortex structures and subcortical areas including the basal ganglia may play a role in behavioral disinhibition disorders. Kluver–Bucy syndrome (KBS), which is one of the better knowns of these syndromes, includes hyperorality, visual agnosia, and hypersexuality, has been reported to occur after temporal lobe and amygdala lesions; however, several patients who had focal lesions in areas other than the temporal cortex and amygdala have been reported to present partial KBS symptoms. Nucleus lentiformis refers to a large portion of the basal ganglia including the putamen and globus pallidus, and specific structures within this broad area are known to be important for reward and value‐based decision making. To date, KBS symptoms including hypersexual behavior associated with nucleus lentiformis lesions have never been reported. Here, we present a 38‐year‐old male patient who developed increased sexual interest and hyperorality after infarctions in the right lenticular nucleus and right occipitotemporal region and committed a first‐degree sexual assault. He was sent to our institution for the assessment of criminal responsibility to the index sexual crime. According to a comprehensive and thorough forensic psychiatric evaluation, he was diagnosed as having an organic personality disorder with partial KBS symptoms. To the best of our knowledge, this is the first reported case of deviant sexual behavior and hyperorality developing after nucleus lentiformis infarction. We aimed to discuss possible neurobiologic explanations of late‐onset deviant sexual behavior, which resulted in sexual criminal behavior following a cerebrovascular infarction.

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Functional brain changes in Parkinson’s disease: a whole brain ALE study

Sheng

et al. 2022

Neurol Sci

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Nucleus lentiformis – A new model for psychiatry?

Cited by 3 publications

References 21 publications

Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study

Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study

Sexual Behavioral Disinhibition Associated with Nucleus Lentiformis Lesion: A Forensic Neuroscience Perspective Through a Case

Functional brain changes in Parkinson’s disease: a whole brain ALE study

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