Nucleus-independent transgenerational small RNA inheritance in
Caenorhabditis elegans
Itai Rieger,
Guy Weintraub,
Itamar Lev
et al.
Abstract:In
Caenorhabditis elegans
worms, epigenetic information transmits transgenerationally. Still, it is unknown whether the effects transfer to the next generation inside or outside of the nucleus. Here, we use the tractability of gene-specific double-stranded RNA–induced silencing to demonstrate that RNA interference can be inherited independently of any nuclear factors via mothers that are genetically engineered to transmit only their ooplasm but not the oocytes’ nuclei to the next genera… Show more
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