Nucleus basalis of Meynert predicts cognition after deep brain stimulation in Parkinson's disease

Kübler, Dorothee; Wellmann, Sophie Katharina; Kaminski, Jakob; Skowronek, Cornelia; Schneider, Gerd‐Helge; Neumann, Wolf‐Julian; Ritter, Kerstin; Kühn, Andrea A.

doi:10.1016/j.parkreldis.2021.12.002

Cited by 13 publications

(22 citation statements)

References 28 publications

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“… 14.4 ± 6.4 mo NR Percent change in UPDRS score: −36.8 (± 27.4) Lu; 2021 22 59 (33/26) 57 BL STN 2 BL GPi 8.2 ± 4.3 PD:65.7 ± 7.5; Control: 59.8 ± 7.1 ↑ The left STN volume & Higher preoperative MMSE and MoCA scores. 6 mo NR NR Kübler; 2022 33 55 (39/16) BL STN 10.8 ± 4.7 61.4 ± 7.5 ↑ NBM volume & Improved cognitive outcome measured by MMSE or DemTect score. 1 yr Med off: 44.2 ± 14.4 Med off: 25.0 ± 12.7 Psychiatric changes Bourne; 2012 16 Confusion 21(/226); 21 controls 14 BL/UL STN 2 BL/UL GPi 5 BL/UL VIM NR Confusion:65.7; Control :65.6 ↑ Minimum width of the lateral ventricles in pts with postoperative confusion relative to pts without.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies that were included in our review reported associations of brain volumetry with the cognitive outcome 15 , 22 , 28 – 33 . ROI analysis assessing specific structures was adopted in these studies.…”

Section: Resultsmentioning

confidence: 99%

“…The volume of NBM was correlated with the relative change of MMSE or DemTect scores of PD patients 1 year after STN-DBS 33 . The results were demonstrated in both the regression model and the machine learning model, where NBM volume was the most predictive variable.…”

Section: Resultsmentioning

confidence: 99%

“…Connections between hippocampal subfields with cognitive functions and motor subtypes of PD patients have been proposed, the study of which might exert increased potential in patient selection with candidate stratified to different motor subtypes 65 , 66 . Other brain structures were also reported to correlate with the cognitive outcome of DBS, including thalamus 30 , nucleus accumbens 15 and NBM 33 . These structures provide important crossroads for cognition-relevant information processing.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease

Wang

Lai

Pan

et al. 2022

npj Parkinsons Dis.

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While the efficacy of deep brain stimulation (DBS) is well-established in Parkinson’s Disease (PD), the benefit of DBS varies across patients. Using imaging features for outcome prediction offers potential in improving effectiveness, whereas the value of presurgical brain morphometry, derived from the routinely used imaging modality in surgical planning, remains under-explored. This review provides a comprehensive investigation of links between DBS outcomes and brain morphometry features in PD. We systematically searched PubMed and Embase databases and retrieved 793 articles, of which 25 met inclusion criteria and were reviewed in detail. A majority of studies (24/25), including 1253 of 1316 patients, focused on the outcome of DBS targeting the subthalamic nucleus (STN), while five studies included 57 patients receiving globus pallidus internus (GPi) DBS. Accumulated evidence showed that the atrophy of motor cortex and thalamus were associated with poor motor improvement, other structures such as the lateral-occipital cortex and anterior cingulate were also reported to correlated with motor outcome. Regarding non-motor outcomes, decreased volume of the hippocampus was reported to correlate with poor cognitive outcomes. Structures such as the thalamus, nucleus accumbens, and nucleus of basalis of Meynert were also reported to correlate with cognitive functions. Caudal middle frontal cortex was reported to have an impact on postsurgical psychiatric changes. Collectively, the findings of this review emphasize the utility of brain morphometry in outcome prediction of DBS for PD. Future efforts are needed to validate the findings and demonstrate the feasibility of brain morphometry in larger cohorts.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease

Wang

Lai

Pan

et al. 2022

npj Parkinsons Dis.

View full text Add to dashboard Cite

show abstract

“…However, non-corrected DTI metrics were not related to cognitive impairment in the cholinergic forebrain but in the hippocampus [ 103 ]. Lower volume of the nbM also predicted cognitive decline in patients undergoing STN-DBS [ 203 ]. Notably, single trajectory DBS targeting both the GPi and nbM did not improve cognition in a recent cross-over trial in 6 PD patients [ 204 ], consistent with previous trials in PD [ 205 ].…”

Section: Regions Of the Limbic Systemmentioning

confidence: 99%

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

et al. 2022

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The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson’s disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.

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Whole‐Brain Magnetic Resonance Spectroscopy Reveals Distinct Alterations in Neurometabolic Profile in Progressive Supranuclear Palsy

et al. 2023

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BackgroundProgressive supranuclear palsy (PSP) is an atypical Parkinsonian syndrome characterized by supranuclear gaze palsy, early postural instability, and a frontal dysexecutive syndrome. Contrary to normal brain magnetic resonance imaging in Parkinson's disease (PD), PSP shows specific cerebral atrophy patterns and alterations, but these findings are not present in every patient, and it is still unclear if these signs are also detectable in early disease stages.ObjectiveThe aim of the present study was to analyze the metabolic profile of patients with clinically diagnosed PSP in comparison with matched healthy volunteers and PD patients using whole‐brain magnetic resonance spectroscopic imaging (wbMRSI).MethodsThirty‐nine healthy controls (HCs), 29 PD, and 22 PSP patients underwent wbMRSI. PSP and PD patients were matched for age and handedness with HCs. Clinical characterization was performed using the Movement Disorder Society Unified Parkinson's Disease Rating Scale, PSP rating scale, and DemTect (test for cognitive assessment).ResultsIn PSP patients a significant reduction in N‐acetyl‐aspartate (NAA) was detected in all brain lobes. Fractional volume of the cerebrospinal fluid significantly increased in PSP patients compared to PD and healthy volunteers.ConclusionsIn PSP much more neuronal degeneration and cerebral atrophy have been detected compared with PD. The most relevant alteration is the decrease in NAA in all lobes of the brain, which also showed a partial correlation with clinical symptoms. However, more studies are needed to confirm the additional value of wbMRSI in clinical practice. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Nucleus basalis of Meynert predicts cognition after deep brain stimulation in Parkinson's disease

Cited by 13 publications

References 28 publications

A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease

A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease

Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms

Whole‐Brain Magnetic Resonance Spectroscopy Reveals Distinct Alterations in Neurometabolic Profile in Progressive Supranuclear Palsy

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