Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography

Storvik, Markus; Tiihonen, Jari; Haukijärvi, Tuija; Tupala, Erkki

doi:10.1016/j.alcohol.2006.12.005

Cited by 15 publications

(9 citation statements)

References 30 publications

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“…Other studies have reported lower SERT binding or availability in brain regions outside the hippocampus in chronic drinkers (Heinz et al, 1998, 2000; Szabo et al, 2004; Storvik et al, 2006a,b, 2007). It is tempting to suggest that SERT density is lower globally in animals and humans exposed to chronic ethanol, but comparisons between the existing literature and our own data are difficult to make due to significant species and methodological differences, most notably the heterogeneity of the samples investigated.…”

Section: Discussionmentioning

confidence: 84%

The Effects of Chronic Ethanol Self-Administration on Hippocampal Serotonin Transporter Density in Monkeys

Burnett¹,

Davenport²,

Grant³

et al. 2012

Front. Psychiatry

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Evidence for an interaction between alcohol consumption and the serotonin system has been observed repeatedly in both humans and animal models yet the specific relationship between the two remains unclear. Research has focused primarily on the serotonin transporter (SERT) due in part to its role in regulating extracellular levels of serotonin. The hippocampal formation is heavily innervated by ascending serotonin fibers and is a major component of the neurocircuitry involved in mediating the reinforcing effects of alcohol. The current study investigated the effects of chronic ethanol self-administration on hippocampal SERT in a layer and field specific manner using a monkey model of human alcohol consumption. [3H]Citalopram was used to measure hippocampal SERT density in male cynomolgus macaques that voluntarily self-administered ethanol for 18 months. Hippocampal [3H]citalopram binding was less dense in ethanol drinkers than in controls, with the greatest effect observed in the molecular layer of the dentate gyrus. SERT density was not correlated with measures of ethanol consumption or blood ethanol concentrations, suggesting the possibility that a threshold level of consumption had been met. The lower hippocampal SERT density observed suggests that chronic ethanol consumption is associated with altered serotonergic modulation of hippocampal neurotransmission.

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Section: Discussionmentioning

confidence: 84%

The Effects of Chronic Ethanol Self-Administration on Hippocampal Serotonin Transporter Density in Monkeys

Burnett¹,

Davenport²,

Grant³

et al. 2012

Front. Psychiatry

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“…macromolecule densities (Tupala et al, 2000,Mantere et al, 2002,Storvik et al, 2006a,Storvik et al, 2006b,Tupala and Tiihonen, 2005,Kupila et al, 2012,Storvik et al, 2009,Storvik et al, 2012 were calculated by the Spearman method, as binding values for different radioligands could not be assumed to be directly comparable. The differences in Spearman correlations between the groups were tested by Fisher's (z)-transformation of correlations to evaluate the overall differences, followed by a Tukey-type test to compare individual groups.…”

Section: Possible Correlations Between [ 3 H] Ampa Binding and Previomentioning

confidence: 99%

“…In this study we examined five different brain regions related to addiction and behavior control, namely the anterior cingulate cortex (ACC), the dentate gyrus (DG), the FC, the hippocampus (Hipp) and the NAc. Secondarily, we aimed to examine correlates of AMPAR densities to previously published results of dopamine transporter (DAT) (Tupala et al, 2000,Tupala et al, 2006, serotonin transporter (SERT) (Mantere et al, 2002,Storvik et al, 2006a,Storvik et al, 2006b, dopamine D1 Tiihonen, 2005,Tupala andTiihonen, 2008), dopamine D2 , metabotropic glutamate 1/5 (mGluR1/5) (Kupila et al, 2012), serotonin 5-HT1A (Storvik et al, 2009) and 5-HT1B (Storvik et al, 2012) receptor densities from these same study subjects.…”

Section: Introductionmentioning

confidence: 99%

AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study

Kärkkäinen

Kupila

Laukkanen

et al. 2013

Psychiatry Research: Neuroimaging

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Dysfunction of the brain glutamate system has been associated with alcoholism. Ionotropic glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) play an important role in both neurotransmission and post-synaptic plasticity. Alterations in AMPAR densities may also play a role in the neurobiological changes associated with alcoholism. In the present study, [(3)H] AMPA binding density was evaluated in the nucleus accumbens (NAc), frontal cortex, anterior cingulate cortex (ACC), dentate gyrus and hippocampus of Cloninger type 1 (n=9) and 2 (n=8) alcoholics, and compared with non-alcoholic control subjects (n=10) by post-mortem whole-hemisphere autoradiography. The [(3)H] AMPA binding density was significantly higher in the ACC of early onset type 2 alcoholics when compared with controls (p=0.011). There was also a significant negative correlation between [(3)H] AMPA binding and previously published results of dopamine transporter (DAT) density in the ACC in these same brain samples (R=-0.95, p=0.001). Although preliminary, and from a relatively small diagnostic group, the present results help to further explain the pathology of alcohol dependence and impulsive behaviour in type 2 alcoholics.

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“…We previously reported on decreased dopamine function in post-mortem brains of Cloninger type 1 alcoholics (Tupala et al, 2000;Tupala and Tiihonen, 2004) and alterations in the serotonergic signaling in both type 1 and type 2 alcoholics (Leggio and Addolorato, 2008;Mantere et al, 2002;Storvik et al, 2006;Storvik et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics

Kärkkäinen

Lehtonen

Laukkanen

et al. 2013

Alcohol

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Accumulating evidence continues to link certain aspects of the endogenous cannabinoid (EC) system with alcohol dependence, negative reinforcement learning and the modulation of stress response.Specific alterations in brain regions that are related to stress and negative reinforcement learning have been reported to exist in Cloninger type 1 and 2 alcoholics. To study possible differences in profiles of ECs between Cloninger type 1 (n=9), type 2 (n=8) alcoholics and non-alcoholic control subjects (n=10), we analyzed post-mortem amygdala and hippocampus brain samples for several ECs by quantitative liquid chromatography with triple quadrupole mass spectrometric detection. A significant difference was found between these three groups in terms of EC profiles in the amygdala (p = 0.037).In particular, this difference was prominent for variations in docosahexaenoylethanolamine levels, which were significantly higher in type 1 alcoholics (p = 0.022) when compared to controls. There was also a large negative correlation between anandamide concentration and mGlu1/5 receptor density in the hippocampus of Cloninger type 1 alcoholics (R=-0.88, p=0.002), which was not seen in type 2 alcoholics or in controls. Although preliminary, and from relatively small diagnostic groups, these results suggest that the EC profile may be altered in the hippocampus and amygdala of type 1 alcoholics.

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Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography

Cited by 15 publications

References 30 publications

The Effects of Chronic Ethanol Self-Administration on Hippocampal Serotonin Transporter Density in Monkeys

The Effects of Chronic Ethanol Self-Administration on Hippocampal Serotonin Transporter Density in Monkeys

AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study

Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics

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