Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats

Beloate, Lauren N.; Weems, Peyton W.; Casey, Graham; Webb, Ian C.; Coolen, Lique M.

doi:10.1016/j.neuropharm.2015.09.023

Cited by 15 publications

(10 citation statements)

References 109 publications

(161 reference statements)

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“…Moreover, we have demonstrated that D1R blockage in the NAcc during the conditioning phase reduced the olfactory preference of males toward female chemosignals more than 10 days later. The reinforcing effects of sexual stimuli are mediated by long-lasting neuroplasticity changes in the NAc (Beloate et al, 2016;Pitchers et al, 2012;Staffend et al, 2014), which are dependent on D1R signaling and its down-stream effects (Pitchers et al, 2013;Staffend et al, 2014). Our results suggest that blocking D1R signaling during the initial interactions with female chemosignals prevented the occurrence of female-induced neuroplasticity in the NAcc, and this altered the olfactory preference of males days later.…”

Section: Discussionmentioning

confidence: 58%

Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice

et al. 2017

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Sexual preference for the opposite sex is a fundamental behavior underlying reproductive success, but the neural mechanisms remain unclear. Here, we examined the role of dopamine signaling in the nucleus accumbens core (NAcc) in governing chemosensory-mediated preference for females in TrpC2 and wild-type male mice. TrpC2 males, deficient in VNO-mediated signaling, do not display mating or olfactory preference toward females. We found that, during social interaction with females, TrpC2 males do not show increased NAcc dopamine levels, observed in wild-type males. Optogenetic stimulation of VTA-NAcc dopaminergic neurons in TrpC2 males during exposure to a female promoted preference response to female pheromones and elevated copulatory behavior toward females. Additionally, we found that signaling through the D1 receptor in the NAcc is necessary for the olfactory preference for female-soiled bedding. Our study establishes a critical role for the mesolimbic dopaminergic system in governing pheromone-mediated responses and mate choice in male mice.

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Section: Discussionmentioning

confidence: 58%

Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice

et al. 2017

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“…MK801 administration (0.6 µg) to the preoptic-anterior hypothalamus in male Wistar rats reduced 50-kHz calls (Brudzynski and Pniak, 2002). In contrast to these studies, infusions of 1 or 2 µg of MK801 to the NAc for 4 consecutive days did not change sexual behavior in male Sprague-Dawley rats (Beloate et al, 2016). The different brain regions targeted may explain this discrepancy between these studies.…”

Section: Manipulating Nmda Receptorsmentioning

confidence: 65%

“…Administration of MK801, either systemically or via microinjections into the brain (mPOA and PVN), diminished male rat sexual behavior (Fleming and Kucera, 1991;Powell et al, 2003;Melis et al, 2004;Dominguez et al, 2007;Vigdorchik et al, 2012;Beloate et al, 2016). In Table 1, we summarized the above studies, as well as subsequent studies reviewed.…”

Section: Manipulating Nmda Receptorsmentioning

confidence: 99%

Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence

Chiang

Park

2020

Front. Behav. Neurosci.

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The survival of animal species predicates on the success of sexual reproduction. Neurotransmitters play an integral role in the expression of these sexual behaviors in the brain. Here, we review the role of glutamate in sexual behavior in rodents and non-rodent species for both males and females. These encompass the release of glutamate and correlations with glutamate receptor expression during sexual behavior. We then present the effects of glutamate on sexual behavior, as well as the effects of antagonists and agonists on different glutamate transporters and receptors. Following that, we discuss the potential role of glutamate on steroid-independent sexual behavior. Finally, we demonstrate the interaction of glutamate with other neurotransmitters to impact sexual behavior. These sexual behavior studies are crucial in the development of novel treatments of sexual dysfunction and in furthering our understanding of the complexity of sexual diversity. In the past decade, we have witnessed the burgeoning of novel techniques to study and manipulate neuron activity, to decode molecular events at the single-cell level, and to analyze behavioral data. They pose exciting avenues to gain further insight into future sexual behavior research. Taken together, this work conveys the essential role of glutamate in sexual behavior.

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“…Furthermore, overexpression of ΔFosB in the Nacc core increases food reinforcement and motivation 81 . Sexual activity-induced ΔFosB expression in the Nacc is dependent upon NMDA receptor activation 82 , a mechanism reminiscent of Levodopa-induced FosB expression in the striatum. Together, these data suggest that enhanced ΔFosB expression following chronic dopamine replacement therapy may contribute to ICD by increasing an individual's motivational drive for rewards like food or sex potentially leading towards compulsive engagement in behaviours such as binge eating or hypersexuality.…”

Section: Genetics and Epigenetics Of Icds And Lidmentioning

confidence: 99%

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update

Voon

Napier

Frank

et al. 2017

The Lancet Neurology

297

217

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Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats

Cited by 15 publications

References 109 publications

Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice

Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice

Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update

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