Nucleus accumbens neurochemistry in human anxiety: A 7 T 1H-MRS study

Strasser, Alina; Xin, Lijing; Gruetter, Rolf; Sandi, Carmen

doi:10.1016/j.euroneuro.2018.12.015

Cited by 37 publications

(26 citation statements)

References 76 publications

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“…However, recent studies showed that stress decreases GABA concentrations in the prefrontal cortex (Strasser et al, 2019;Hasler, van der Veen, Grillon, Drevets, & Shen, 2010; but see also Houtepen et al, 2017). Therefore, it may possible that psychological stress, as for instance being in the scanner, serves as a confounding variable, which may affect GABA concentrations differentially in healthy controls and T2D patients.…”

Section: Discussionmentioning

confidence: 99%

Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction

Thielen

Gancheva

Hong

et al. 2019

Human Brain Mapping

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Type 2 diabetes (T2D) is associated with an accelerated episodic memory decline, but the underlying pathophysiological mechanisms are not well understood. Hallmarks of T2D comprise impairment of insulin secretion and insulin sensitivity. Insulin signaling modulates cerebral neurotransmitter activity, including the excitatory glutamate and inhibitory gamma‐aminobutyric acid (GABA) systems. Here we tested the hypothesis that the glutamate and GABA systems are altered in T2D patients and this relates to memory decline and insulin resistance. Using 1H‐magnetic resonance spectroscopy (MRS), we examined glutamate and GABA concentrations in episodic memory relevant brain regions (medial prefrontal cortex and precuneus) of T2D patients and matched controls. Insulin sensitivity was measured by hyperinsulinemic‐euglycemic clamps and memory performance was assessed using a face‐profession associations test. T2D patients exhibited peripheral insulin resistance and had a decreased memory for face‐profession associations as well as elevated GABA concentration in the medial prefrontal cortex but not precuneus. In addition, medial prefrontal cortex GABA concentration was negatively associated with memory performance suggesting that abnormal GABA levels in the medial prefrontal cortex are linked to the episodic memory decline that occurs in T2D patients.

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Section: Discussionmentioning

confidence: 99%

Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction

Thielen

Gancheva

Hong

et al. 2019

Human Brain Mapping

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“…Targeted mitochondrial defects even cause mood disorder-like phenotypes in animals 38 and are likely implicated in the etiology of psychiatric, neurological and degenerative disorders in humans 39 . Moreover, in vivo human brain metabolic imaging studies show that energy metabolism in specific brain areas (e.g., nucleus accumbens, NAc) predict performance and anxiety [40][41][42] . Thus, current evidence positions mitochondria as an upstream modulator of brain function and behavior.…”

Section: Introductionmentioning

confidence: 99%

Brain mitochondrial diversity and network organization predict anxiety-like behavior in mice

Rosenberg

Saggar

Rogu

et al. 2021

Preprint

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The brain and behavior are under energetic constraints, which are likely driven by mitochondrial energy production capacity. However, the mitochondria-behavior relationship has not been systematically studied on a brain-wide scale. Here we examine the association between mitochondrial health index and stress-related behaviors in mice with diverse mitochondrial and behavioral phenotypes. Miniaturized assays of mitochondrial respiratory chain function and mitochondrial DNA (mtDNA) content were deployed on 571 samples from 17 brain regions. We find specific patterns of mito-behavior associations that vary across brain regions and behaviors. Furthermore, multi-slice network analysis applied to our brain-wide mitochondrial dataset identified three large-scale networks of brain regions. A major network composed of cortico-striatal regions exhibits highest mitochondria-behavior correlations, suggesting that this mito-based network is functionally significant. Mito-based networks can also be recapitulated using correlated gene expression and structural connectome data, thereby providing convergent multimodal evidence of mitochondrial functional organization anchored in gene, brain and behavior.

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“…Concerning the OF test, the administration of increasing taurine doses seems to significantly decrease ambulation, latency scores and thigmotaxis, without affecting rearing and defecation [32]. Moreover, a human study using proton magnetic resonance spectroscopy indicated that trait anxiety and state physical fatigue might be negatively associated with nucleus accumbens taurine content [33].…”

Section: Neurochemical Findingsmentioning

confidence: 99%

Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content and Sideritis Extract in Female Mice

et al. 2020

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The aim of this study was to determine the cognitive and behavioral effects of extra virgin olive oil total phenolic content (TPC) and Sideritis (SID) extracts in female mice, and identify the associated neurochemical changes in the hippocampus and the prefrontal cortex. All animals received intraperitoneal low or high doses of TPC, SID or vehicle treatment for 7 days and were subjected to the Open Field (OF), Novel Object Recognition (NOR) and Tail Suspension Test (TST). The prefrontal cortex and hippocampus were dissected for analysis of neurotransmitters and aminoacids with high performance liquid chromatography with electrochemical detection (HPLC-ED). Both TPC doses enhanced vertical activity and center entries in the OF, which could indicate an anxiolytic-like effect. In addition, TPC enhanced non-spatial working memory and, in high doses, exerted antidepressant effects. On the other hand, high SID doses remarkably decreased the animals’ overall activity. Locomotor and exploratory activities were closely associated with cortical increases in serotonin turnover induced by both treatments. Cognitive performance was linked to glutamate level changes. Furthermore, TPC reduced cortical taurine levels, while SID reduced cortical aspartate levels. TPC seems to have promising cognitive, anxiolytic and antidepressant effects, whereas SID has sedative effects in high doses. Both extracts act in the brain, but their specific actions and properties merit further exploration.

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Nucleus accumbens neurochemistry in human anxiety: A 7 T 1H-MRS study

Cited by 37 publications

References 76 publications

Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction

Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction

Brain mitochondrial diversity and network organization predict anxiety-like behavior in mice

Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content and Sideritis Extract in Female Mice

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