Nucleotides and nucleosides: direct route to condensed pyridinethione carbocyclic nucleosides related to 3-deazauridine

Novel Synthesis of a New Class of Strongly Fluorescent Phenanthridine Analogues†

“…IR spectra were obtained (KBr discs) on a Pye Unicam Spectra-1000. 1 H NMR were measured on a Wilmad 270 MHz or on a Varian 400 MHz spectrometer for solutions in (CD 3 ) 2 SO using SiMe 4 as internal standard. Mass spectra were recorded on a Varian MAT 112 spectrometer.…”

“…Continuing our interest in the development of efficient and simple procedures for the synthesis of antimetabolites, [1][2][3] we have recently reported successful syntheses of sulfanyl purine and 3-deazapyrimidine nucleosides and of folic acid analogues. [4][5][6] Here we report novel syntheses of phenanthridine analogues and their condensed derivatives as a possible new class of laser dye.…”

A novel and efficient method for the synthesis of 6-amino-pyrimidine-2(1H)-thiones derivatives, pyrido [2,3-d] pyrimidine-2(1H)-thiones derivatives and their glycosides

“…The pyrimidinethione nucleosides were recently occupied a significant position in the search for effective antiviral agents and exert inhibitory effects on both DNA and RNA containing viruses (Elgemeie et al, 1990(Elgemeie et al, , 1995(Elgemeie et al, , 1997(Elgemeie et al, and 2002a. During our studies of nucleoside analogues with novel H-bonding patterns (Elgemeie et al, 1989(Elgemeie et al, , 1994(Elgemeie et al, and 2002b. A route for the synthesis of N-or S-nucleosides bearing a substituted pyrimidine ring as a heterocyclic was desired ( (Elgemeie et al, 1995 and2000) and such a route could provide access to a varity of analoguses of pyrimidine nucleosides with novel H-bonding patterns, such nucleosides might serve as components of an expanded genetic "alphabet" of display pharmaceutically useful antimetabolite activity (Elgemeie et al, 1999;Khalil, 2006;2007).…”

The Reaction of Dimethyl N-cyanodithioiminocarbonate with Amino- and Oxo-azoles: A New General Synthesis of Methylsulfanylazoloazines

“…1,2 We are developing new procedures for the synthesis of thioguanine and mercaptopurine analogues and other antimetabolites. [3][4][5] We have recently reported different successful approaches for the synthesis of mercaptopurine analogues using ketene dithioacetals. [6][7][8] In an extension to this work, we now report a novel synthesis of methylsulfanylazoloazines by the reaction of dimethyl N-cyanodithioiminocarbonate 2 with diazoles containing amino and active methylene functions.…”