NUCLEOTIDE VARIANCE OF MITOCHONDRIAL DNA D-Loop 126 bp (nt: 34-159) REGION  IN MADURESE

Sulistyorini, Nilly; Yudianto, Ahmad; Margaret, Nola

doi:10.20473/fmi.v52i2.5215

Cited by 1 publication

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“…The discrepancies in the results among the selected studies might be attributed to the ethnicity of the subjects involved. Genetic information contains historical, anthropological, and statistical characteristics that vary across ethnicities (Sulistyorini et al 2017. According to research conducted by Bhanushali et al (2017), minor allele frequency was more common in Utah (US) residents of Northern and Western European ancestry, as well as Gujarati Indians in Houston (US), whereas allelic frequency differences were more common in Han Chinese in Beijing (China), Yoruba in Ibadan (Nigeria), and Japanese in Tokyo (Japan).…”

Section: Wide Association Study (Gwas) Conducted In 2007mentioning

confidence: 99%

Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation

Putra

Dharmadjati

Pikir

et al. 2023

FMI

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Highlights: A genetic variable has been identified as an atrial fibrillation risk factor Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.

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Section: Wide Association Study (Gwas) Conducted In 2007mentioning

confidence: 99%

Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation

Putra

Dharmadjati

Pikir

et al. 2023

FMI

View full text Add to dashboard Cite

show abstract

NUCLEOTIDE VARIANCE OF MITOCHONDRIAL DNA D-Loop 126 bp (nt: 34-159) REGION IN MADURESE

Abstract: ABSTRAK Perkawinan dalam masyarakat di pulau madura pada daerah pelosok terutama daerah kepulauan terkecil madura masih terjadi antara kalangan mereka sendiri (endogami).

Cited by 1 publication

References 9 publications

Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation

Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation

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