Nucleotide sequence of the BALB/c H-2T region gene, T3 d

Mashimo, Hiroshi; Chorney, Michael J.; Pontarotti, Pierre; Fisher, Douglas A.; Hood, Leroy; Nathenson, Stanley G.

doi:10.1007/bf00215662

Cited by 11 publications

(12 citation statements)

References 35 publications

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“…H2-Bl is expressed in mouse preimplantation blastocysts and in the placenta. Tw3 bc is very similar to the H2-T3 gene already sequenced from the b, d, and k haplotypes (Obata et al 1985;Pontarotti et al 1986;Mashimo et al 1992), where it encodes the TL antigen expressed in the intestinal epithelium (Wu et al 1991). Both Tw5 and Tw3 encode the consensus residues characteristic of peptide-binding class I molecules (Fig.…”

Section: Class I Genesmentioning

confidence: 80%

Species-Specific Class I Gene Expansions Formed the Telomeric 1 Mb of the Mouse Major Histocompatibility Complex

et al. 2003

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We have determined the complete sequence of 951,695 bp from the class I region of H2, the mouse major histocompatibility complex (Mhc) from strain 129/Sv (haplotype bc). The sequence contains 26 genes. The sequence spans from the last 50 kb of the H2-T region, including 2 class I genes and 3 class I pesudogenes, and includes the H2-M region up to Gabbr1. A 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two subfamilies, M1 and M10, distinct from other mouse class I genes. This M1/M10 class I gene-cluster is separated from the centromeric H2-T and the telomeric H2-M4, -5 and -6 class I genes by "nonclass I genes". Comparison with the corresponding 853-kb region of the human Mhc, which includes the HLA-A region, shows a mosaic of conserved regions of orthologous nonclass I genes separated by regions of species-specific expansion of paralogous Mhc class I genes. The analysis of this mosaic structure illuminates the dynamic evolution of the Mhc class I region among mammals and provides evidence for the framework hypothesis.

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Section: Class I Genesmentioning

confidence: 80%

Species-Specific Class I Gene Expansions Formed the Telomeric 1 Mb of the Mouse Major Histocompatibility Complex

et al. 2003

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“…The transcripts of some other H2‐M and H2‐T genes are expressed widely, including in the brains of adult and embryonic mice . Many reports are published concerning the gene function of the non‐classical MHC class Ib genes …”

Section: Genomic Comparison Among Human Rhesus Macaque and Mousementioning

confidence: 99%

Comparative genomics of the human, macaque and mouse major histocompatibility complex

et al. 2016

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SummaryThe MHC is a highly polymorphic genomic region that encodes the transplantation and immune regulatory molecules. It receives special attention for genetic investigation because of its important role in the regulation of innate and adaptive immune responses and its strong association with numerous infectious and/or autoimmune diseases. The MHC locus was first discovered in the mouse and for the past 50 years it has been studied most intensively in both mice and humans. However, in recent years the macaque species have emerged as some of the more important and advanced experimental animal models for biomedical research into MHC with important human immunodeficiency virus/simian immunodeficiency virus and transplantation studies undertaken in association with precise MHC genotyping and haplotyping methods using Sanger sequencing and next-generation sequencing. Here, in this special issue on 'Macaque Immunology' we provide a short review of the genomic similarities and differences among the human, macaque and mouse MHC class I and class II regions, with an emphasis on the association of the macaque class I region with MHC polymorphism, haplotype structure and function.

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“…Clearly, a detailed sequence examination ofthe TL genes was necessary. Six TL genes from laboratory mice were isolated and sequenced (31)(32)(33)(34)(35). It With seven sequenced TL genes, the data set is one of the largest among murine class I genes.…”

mentioning

confidence: 99%

“…The seven TL genes analyzed in this study are Tlaw-1 of M. m. molossinus MSM, a Japanese wild mouse inbred strain (GenBank accession no. D14027), T3b of C57BL/6 (31), T3d (35) and Tl8d (32) of BALB/c, and Tlaa-1, Tlaa-2, and Tlaa-3 of A-strain mice (33). T3b and T3d are allelic, whereas the allelism of the remaining genes has not been established.…”

mentioning

confidence: 99%

Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex.

Obata

Satta

Moriwaki

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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In contrast to well-studied "classal" class I genes of the major htmpatibility complex (MHC), the biology of noncll dass I genes remains largely unexamined. The mouse TL genes constitute one of the best defined systems among class I genes In the T region of the MHC. To eucidate the function and the evolution of TL genes and their relationship to cl l class I genes, seven TL DNA sequences, including one from a Japanese wild mouse, were examined and compared with those of several mouse and human classical class I genes. The TL genes differ from either clascal class I genes or pseudogenes in the extent and pattern of nucleotide substutins. Natural selection appears to have operated so as to preserve the function of TL, which might have been acquired in an early stage of its evolution. In a putative peptide-bindngregion encoded by TL genes, the rate of nonsynonymous (amino acid replacing) substitution is considerably lower than that of synonymous substitution. This conservation is completely opposite that in classical clas I genes, in which the peptide-binding region has evolved to diveify amino acd sequences so as to recognize a variety of antigens. Thus, it is ggested that the function of TL antigens is distinct from that of c al class I antigens and is related to the recognition of a relatively restricted repertoire of antigens and their presentation to T-cell receptors.

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Nucleotide sequence of the BALB/c H-2T region gene, T3 d

Cited by 11 publications

References 35 publications

Species-Specific Class I Gene Expansions Formed the Telomeric 1 Mb of the Mouse Major Histocompatibility Complex

Species-Specific Class I Gene Expansions Formed the Telomeric 1 Mb of the Mouse Major Histocompatibility Complex

Comparative genomics of the human, macaque and mouse major histocompatibility complex

Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex.

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