“…These enzymes catalyze oxidation-reduction reactions in a variety of cellular pathways, such as glucose metabolism (AKR1B1) (2), vitamin C biosynthesis (AKR1A1) (6), steroid and prostaglandin metabolism (AKR1Bs and AKR1Cs) (7,8), bile acid synthesis (AKR1D1) (9), and neurotransmitter metabolism (AKR7) (10), as well as the detoxification of both endogenous oxidation by-products, such as advanced glycation end product precursors or lipid peroxidation-derived aldehydes (11,12), and exogenous toxins, such as aflatoxin B1 (13) or tobacco-derived carcinogen 4-methyl-nitrosamino-1-(3-pyri-dyl)-1-butanone (NNK) (14). Generally, the enzymes of the AKR superfamily prefer NADPH over NADH as a reducing cofactor (2,15,16).…”