“…The equivalent region of the proteinase domain of the polyprotein encoded by bymovirus RNA-2 does not, however, appear to contain this motif. This could correlate with HC-Pro : RNA binding in cis during the replication of HBE Review : picornavirus proteinases Review : picornavirus proteinases ;Ghabrial, et al, 1990) ; barley yellow mosaic virus (BYMV ; Kashiwazaki et al, 1989) ; Johnson grass mosaic virus (JGMV ; Gough & Shukla, 1993) ; pea seed-borne mosaic virus (PSBMV ; Johansen et al, 1991) ; peanut stripe virus (PSV ; Gunasinghe et al, 1994) ; pepper mottle virus (PMV ; Vance et al, 1992) ; plum pox virus strain D [PPV(D) ; Teycheney et al, 1989] ; aphid non-transmissible plum pox virus [PPV(NAT) ; Maiss et al, 1989] ; plum pox potyvirus isolate SK68 [PPV(SK68) ; Palkovics et al, 1993] ; Potato virus A [PV(A) ; Puurand et al, 1994] ; potato virus Y [PV(Y) ; Robaglia et al, 1989] ; shallot potyvirus (SPV ; S. K Zavriev and others, unpublished) ; tobacco etch virus (TEV ; Allison et al, 1986) ; tobacco vein mottling virus (TVMV ; Domier et al, 1986) ; turnip mosaic potyvirus (TuMV ; Kim et al, 1995) ; soybean mosaic virus (SMV ; Ghabrial et al, 1990) Review : picornavirus proteinases Review : picornavirus proteinases RNA since HC-Pro is encoded by RNA-1 (analogous to the picornavirus 3CD : RNA interactions), whereas the equivalent proteolytic domain in bymoviruses is encoded on RNA-2 which is replicated in trans and, therefore, is unable to interact with RNA in cis as a replicative function.…”