Nucleotide‐Selective Templated Self‐Assembly of Nanoreactors under Dissipative Conditions

Abstract

Nature adopts complex chemical networks to finely tune biochemical processes.I ndeed, small biomolecules play ak ey role in regulating the flux of metabolic pathways. Chemistry,w hichw as traditionally focused on reactions in simple mixtures,i sd edicating increasing attention to the network reactivity of highly complex synthetic systems,a ble to displayn ew kinetic phenomena. Herein, we showt hat the addition of monophosphate nucleosides to am ixture of amphiphiles and reagents leads to the selective templated formation of self-assembled structures,w hich can accelerate ar eaction between two hydrophobic reactants.T he correct matching between nucleotide and the amphiphile head group is fundamental for the selective formation of the assemblies and for the consequent up-regulation of the chemical reaction. Transient stability of the nanoreactors is obtained under dissipative conditions,d riven by enzymatic dephosphorylation of the templating nucleotides.These results show that small molecules can play ak ey role in modulating network reactivity,b ys electively templating self-assembled structures that are able to up-regulate chemical reaction pathways.

Transient Biomacromolecular Nanoparticles for Labels with Self‐Erasable and Rewritable Ability

“…Inspired by naturally occurring systems, synthetic molecules have been used as building blocks in non‐equilibrium self‐assembly systems. To date, various building blocks have been explored in the non‐equilibrium self‐assembly, such as small molecules, [4–13] copolymer, [14–17] peptide, [18,19] protein, [20,21] RNA, [22] DNA, [23–28] etc. Meanwhile, driven by chemical fuels, many kinds of transient structures, such as nanoparticles, [29–31] micelles, [15,32] vesicles, [6,10,33,34] aggregates, [16,35,36] fibers, [37,38] and hydrogels [39–44] have been studied.…”