Nucleotide excision repair and anti-cancer chemotherapy

Reed, Eddie

doi:10.1007/978-94-017-2374-9_12

Cited by 12 publications

(14 citation statements)

References 55 publications

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“…Both repair pathways are fundamental for the removal of a vast spectrum of DNA lesions and they process DNA damage in a broadly similar way by cleaving the damaged site and leaving DNA breaks behind. These breaks reflect the excision phase of the repair process that has been recognized as the rate-limiting step (29), and is measurable by the well-established comet assay technique. To assess DRC, diversely modified comet-based assays have been developed (30).…”

Section: Discussionmentioning

confidence: 99%

Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas

Slyšková

Korenkova

Collins

et al. 2012

Clinical Cancer Research

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Purpose: DNA repair capacity (DRC) is a determinant not only of cancer development but also of individual response to therapy. Previously, altered base and nucleotide excision repair (BER and NER) have been described in lymphocytes of patients with sporadic colorectal cancer. We, for the first time, evaluate both excision repair capacities in human colon biopsies to study their participation in colorectal tumorigenesis.Experimental design: Seventy pairs of tumor and adjacent healthy tissues were analyzed for BER-and NER-specific DRC by a comet repair assay. Tissue pairs were further compared for expression levels of a panel of 25 BER and NER genes complemented by their promoter methylation status.

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Section: Discussionmentioning

confidence: 99%

Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas

Slyšková

Korenkova

Collins

et al. 2012

Clinical Cancer Research

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“…They are responsible for the simultaneous resistance to several different chemotherapeutic agents (multidrug resistance), as they transport these toxic substances out of the cells [84] . Other mechanisms include the augmented DNA repair, effects on the cell cycle, and altered intracellular drug metabolism [85,86] .…”

Section: Causes Of Drug Resistancementioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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Abstract:Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Hyperthermia can be induced with an alternating magnetic field, providing another therapeutic option. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of " theranostics " . The multifaceted and promising results of research in the recent years offer the prospect of a real advance in cancer therapy in the near future.

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“…6,7 DNA damage excision is rate limiting to the process. In DNA damage excision, the last sub-step is the 5 0 incision into the DNA strand, relative to the site of covalent damage.…”

Section: Introductionmentioning

confidence: 99%