Nucleophilic substitution of the acetoxy group in 3-methylbenzoylaminomethyl acetate

Electrochemical Decarboxylative N-Alkylation of Heterocycles

“…Aside from the highlighted application in Scheme A (pyrazole 1 ), a small selection of additional known compounds were targeted, such as pyrazoles 70 – 72 (Scheme A). − Hemiaminals 70 and 71 could be accessed in high yields in one simple step versus the multistep procedures used in the past. Finally, the tert- butylated pyrazole 72 could be accessed in a single step (although in low yield due to an extended reaction time needed with pivalic acid).…”