Nucleophilic Radiofluorination Using Tri-tert-Butanol Ammonium as a Bifunctional Organocatalyst: Mechanism and Energetics

Abstract

We present a quantum chemical analysis of the 18F-fluorination of 1,3-ditosylpropane, promoted by a quaternary ammonium salt (tri-(tert-butanol)-methylammonium iodide (TBMA-I) with moderate to good radiochemical yields (RCYs), experimentally observed by Shinde et al. We obtained the mechanism of the SN2 process, focusing on the role of the –OH functional groups facilitating the reactions. We found that the counter-cation TBMA+ acts as a bifunctional promoter: the –OH groups function as a bidentate ‘anchor’ bridging the nucleophile [18F]F− and the –OTs leaving group or the third –OH. These electrostatic interactions cooperate for the formation of the transition states of a very compact configuration for facile SN2 18F-fluorination.

Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives

“…Use of ILs for synthesizing 18 F-labeled radiophamaceutical substances also looks promising. Although not an IL, the recently reported reaction of 18 F-fluorination by a tert -butanol-integrated quaternary ammonium salt (tri-( tert -butanol)-methylammonium fluoride [ 83 , 84 ] shows this possibility.…”