Nucleolar Organizer Regions in Prostate Cancer

Kobayashi, Satoru; Kuriyama, Manabu; Yamamoto, Naoki; Takahashi, Yūzō; I, Shinoda; Takeuchi, Toshimi; Deguchi, Takashi; Kawada, Yukimichi

doi:10.1007/978-1-4615-3398-6_19

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…Peripheral carcinomas have high numbers of AgNORs, in contrast to the central incidental carcinomas, with values corresponding to the different grading [3,26]. No difference has been found between incidental and peripheral carcinomas showing no sign of progression [5,22]. In the present study we found no overlapping among the significantly different groups.…”

Section: Discussioncontrasting

confidence: 40%

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Nucleolar organizer regions in low- and high-grade carcinomas of the prostate

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Riede

1995

World J Urol

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The number of silver-stained nucleolar organizer regions (AgNORs) and the status of nucleoli were studied in biopsies from 10 cases of normoglandular prostatic tissue and the findings were compared with the results obtained for 10 cases of hyperplastic prostatic tissue (BPH) and 74 cases of prostatic carcinoma of various grades of malignancy. There was an increase in the number of AgNORs detected between the grade of malignancy found in highly versus poorly differentiated carcinomas of the prostate. Furthermore AgNOR values differed significantly among the groups compared (P < 0.001). The nucleolar status confirmed these differences. In addition, the significantly different survival of patients suffering from prostatic carcinomas support our idea of subdividing GII carcinomas into group IIa (low risk) and group IIb (high risk). This subgrading implies the possibility of preoperatively identifying patients with a prostate carcinoma of high malignancy within the GII carcinoma group.

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Section: Discussioncontrasting

confidence: 40%

“…Kobayashi et al [22] have divided patients with prostatic carcinoma and low or high AgNOR values into two groups. Patients with carcinomas displaying low AgNOR values had significantly longer periods of stabilized disease during follow-up than did the group of patients with carcinomas exhibiting high AgNOR values.…”

Section: Discussionmentioning

confidence: 99%

Nucleolar organizer regions in low- and high-grade carcinomas of the prostate

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Riede

1995

World J Urol

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“…Some studies evaluated the prognostic value of Ag-NOR counts in PCa. Masai and Kobayashi found no correlation between AgNOR counts and response to endocrine therapy [23,24]. Cohen et al could not find significant difference between counts of patients who died of PCa and of those who survived [2].…”

Section: Discussionmentioning

confidence: 95%

Evaluation of three different AgNOR counting methods in advanced carcinoma of the prostate

et al. 1995

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We applied the silver staining of nucleolar organizer regions (AgNOR) technique to the pretreatment biopsies of 50 cases of advanced prostate cancer. Three different counting methods were utilized in the enumeration of AgNORs. All methods yielded statistically significant differences of mean AgNOR counts of groups defined by high and low WHO, and by Gleason grades. However, there was overlap among groups, and further analysis of counts by grouping of patients according to their stage, response to treatment, and prognosis was not conclusive. Replicate counts were performed in 10 cases. While intraobserver reproducibility was high by all methods, only the second counting method yielded nonsignificant interobserver variability. There was a significant intratumoral heterogeneity of AgNOR scores. Lack of technical standardization, low reproducibility, and lack of correlation with prognosis limit the use of AgNOR counts in advanced carcinoma of the prostate.

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“…Auch mit Hilfe dieser Methode ist nur eine äußerst geringfügige Zellproliferation nachvollziehbar. Für normales Prostatagewebe wurden AgNOR-Werte pro Kern von 1,76 und für die BPH von 1,40 bis 1,88 gemessen (24). Diese geringen Durchschnittswerte von 1,7 bis 1,8 entsprechen auch Angaben von Konishi et al 1993 (25) xmdSakr et al 1993 (41).…”

Section: Bph Und Zellproliferationunclassified

“…Gutartige Tumoren sind durch niedrige, maligne Tumoren durch hohe AgNOR-Dichten charakterisiert. So haben auch vergleichende Untersuchungen von BPH und Prostatakarzinomen signifikante Unterschiede in der Zahl der nukleolen-organisierenden Regionen pro Kern ergeben (10,11,14,24,25,29,41,44). Im folgenden sollen Untersuchungsergebnisse über das Verhalten von nukleolen-organisierenden Regionen (NORs) in den Kernen sowohl von Stroma wie von Drüsenzellen mitgeteilt werden, die bei Patienten mit benigner Prostatahyperplasie ohne und mit Prostatitis erhoben wurden.…”

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Benigne Prostatahyperplasie (BPH) und Prostatitis. Eine histomorphologische und zellkinetische Analyse

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Thomas²

1995

Aktuel Urol

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Nucleolar Organizer Regions in Prostate Cancer

Cited by 6 publications

References 13 publications

Nucleolar organizer regions in low- and high-grade carcinomas of the prostate

Nucleolar organizer regions in low- and high-grade carcinomas of the prostate

Evaluation of three different AgNOR counting methods in advanced carcinoma of the prostate

Benigne Prostatahyperplasie (BPH) und Prostatitis. Eine histomorphologische und zellkinetische Analyse

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