Nucleolar organizer regions in meningioma

Orita, Tetsuji; Kajiwara, Kohji; Nishizaki, Takafumi; Ikeda, Norio; Kamiryo, Toshifumi; Aoki, Hideo

doi:10.1097/00006123-199001000-00006

Cited by 43 publications

(18 citation statements)

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“…Detailed discussions on the methodology of PCNA [13,14,26] and AgNORs [10,15,25] are given elsewhere. Comparison of the results of this study with those reported in literature on the PCNA index [17] and AgNOR index [9,24,28] in meningioma, showed that the values for NON and benign meningiomas were almost equal. Comparison of the results of this study with those reported in literature on the PCNA index [17] and AgNOR index [9,24,28] in meningioma, showed that the values for NON and benign meningiomas were almost equal.…”

Section: Discussionsupporting

confidence: 67%

Invasive meningioma: A tumour with high proliferating and ?recurrence? potential

et al. 1995

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A study was undertaken to investigate the correlation between histological invasiveness and proliferating potential and clinical recurrence in meningioma. In 39 meningiomas, the histological findings at the tumour-brain interface zone were classified into 3 types, consisting of 29 cases of non-invasion (NON). 7 cases of nodular invasion (NOD), and 3 cases of intermingled invasion (INT). Proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer region (AgNOR) indices were studied. PCNA indices (mean +/- standard error) of NON, NOD. and INT were 1.7 +/- 0.1%, 5.2 +/- 0.5%, and 7.5 +/- 0.7%. respectively, and the AgNOR indices (dot number/nucleus) were 1.50 +/- 0.03, 2.00 +/- 0.04, and 2.22 +/- 0.07, respectively. Significant differences were found among the three types in both parameters. Clinically, tumour recurrence was observed in 1/29 NON, 4/7 NOD, and 2/2 INT cases, indicating a higher incidence of recurrence in invasive meningiomas (NOD plus INT). Four of 32 patients who underwent gross total removal of the tumours showed recurrence, and all of these four tumours were invasive meningiomas. The results of the present study showed that tumour invasiveness as measured by PCNA + AgNOR indices correlated well with high proliferative potential and clinical recurrence.

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Section: Discussionsupporting

confidence: 67%

Invasive meningioma: A tumour with high proliferating and ?recurrence? potential

et al. 1995

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“…Our results show that AgNORs in skin tissue are also an index of proliferation, as was already demonstrated in tumor tissue [2,5,17]. Our findings revealed no significant differences between intravital versus postmortem results, except a notable difference in the peaks, intravitally after 32 h, and after 36 h postmortem.…”

Section: Discussionsupporting

confidence: 79%

AgNORs during the process of wound healing

Godoy

Oehmichen

2000

International Journal of Legal Medicine

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Silver staining of paraffin sections to detect changes in nucleolar organizer regions (AgNORs) is an established method for detecting cellular proliferation. To determine whether AgNORs are helpful in assessing wound age and vitality, we examined intravital and postmortem skin biopsies from rats surviving incised wounds to both pinnae for defined intervals up to 384 h using, 7 rats per time interval. One biopsy was taken immediately before death, a second 24 h after been sacrificed and storage at 8 degrees C. Interactive computer-assisted image analysis revealed that in the first 120 h after trauma the total number of AgNORs, the mean AgNOR sum area in the nucleus, and the mean AgNOR area per nucleus were dependent on survival time. Taken as indicators of proliferative activity these morphological phenomena revealed an increase in proliferative activity after survival times ranging from 10 to a maximum of 96 h. The findings were the same in both intravital and postmortem biopsies. These findings are in accordance with those obtained using bromodeoxyuridine. The value of these experimental findings in assessing wound age of human beings is discussed.

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“…Routinely processed formalin-fixed tissue may be utilized and the AgNORs are easily identified and quantitated with the use of light microscopy. Several studies have applied this technique and suggested that AgNOR enumeration can be useful in estimating the proliferative potential of neoplasms in the practice of surgical pathology (13)(14)(15)(16)(17). Other groups have applied AgNOR technology to bone pathology (18,19) and recently a study evaluating giant cell tumors of bone was initiated (20).…”

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confidence: 99%

Giant cell lesions of the jaws: evaluation of nucleolar organizer regions in lesions of varying behavior

Whitaker

Vigneswaran

Budnick

et al. 1993

J Oral Pathology Medicine

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To examine whether giant cell lesions of the jaws (GCL) of varying behavior could be separated histologically, a number of GCL were studied using the AgNOR staining technique for nucleolar organizer regions. The mean AgNOR count of mononuclear cells from recurrent lesions (1.73 +/- 0.15) was slightly higher than that of the aggressive lesions (1.54 +/- 0.21) and much higher than that of the non-aggressive/non-recurrent lesions (1.33 +/- 0.14). Similarly, the mean AgNOR count of the multinucleate giant cells of the recurrent lesions (1.52 +/- 0.14) was slightly higher than that of aggressive lesions (1.34 +/- 0.092) and much higher than that of non-aggressive/non-recurrent lesions (1.26 +/- 0.05). Statistical analysis showed a significant difference between the mean number of AgNORS of recurrent lesions and non-recurrent/non-aggressive ones in both the mononuclear and multinuclear population (p < 0.05).

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Nucleolar organizer regions in meningioma

Cited by 43 publications

References 0 publications

Invasive meningioma: A tumour with high proliferating and ?recurrence? potential

Invasive meningioma: A tumour with high proliferating and ?recurrence? potential

AgNORs during the process of wound healing

Giant cell lesions of the jaws: evaluation of nucleolar organizer regions in lesions of varying behavior

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