Abstract:Activation of ErbB receptors--HER2/ErbB2 and EGFR/ErbB1--disrupts 3D multicellular organization of breast-epithelial cells with characteristics resembling premalignant escape from ductal carcinoma in situ (DCIS). However, the escape phenotype is infrequent, and a mechanism for its incomplete penetrance has been elusive. By matching phenotype penetrance to the frequency of transcriptomic fluctuations that co-occur, we uncovered a karyopherin network regulating nucleocytoplasmic transport of ErbBs. The exportin … Show more
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