Abstract:Nucleocytoplasmic trafficking describes the process whereby molecules destined for the nucleoplasm or cytoplasm move across the nuclear envelope. This transport regulates transcription and translation by respective control of transnuclear movements of transcription factors and messenger RNA. Transport across the nuclear envelope occurs through large MDa pores embedded in the inner and outer nuclear membranes, and is a dynamic, adaptable process modulated by biochemical and biophysical cellular milieus. The pre… Show more
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