Nucleocapsid condensation drives Ebola viral factory maturation and dispersion
Melina Vallbracht,
Bianca S. Bodmer,
Konstantin Fischer
et al.
Abstract:SummaryReplication and genome encapsidation of many negative-sense RNA viruses take place in virus-induced membrane-less organelles termed viral factories (VFs). While liquid properties of VFs are believed to control the transition from genome replication to encapsidation, the nucleocapsid assembly, VF maturation and interactions with the cellular environment remain elusive. Here we applyin situcryo-correlative light and electron tomography to follow nucleocapsid assembly and changes in VF morphology and their… Show more
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