Nucleic acid therapeutics as differentiation agents for myeloid leukemias
Olivia Kovecses,
François E. Mercier,
Maureen McKeague
Abstract:Differentiation therapy has proven to be a success story for patients with acute promyelocytic leukemia. However, the remaining subtypes of acute myeloid leukemia (AML) are treated with cytotoxic chemotherapies that have limited efficacy and a high likelihood of resistance. As differentiation arrest is a hallmark of AML, there is increased interest in developing differentiation-inducing agents to enhance disease-free survival. Here, we provide a comprehensive review of current reports and future avenues of nuc… Show more
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