“…Xie et al first reported the biodistribution of Au nanoshell-coated silica cores, radiolabeled with 64 Cu via bifunctional chelating agent DOTA, in head and neck squamous cell carcinoma (HNSCC) xenograft-bearing rats. [192] In addition to nanoshells [193, 194], chelator-based PET studies have extensively been carried out for other AuNP morphologies like nanospheres [195–198], hollow nanospheres[199, 200], nanostars[180], nanocages[201], nanorods[202], nanotripods[203], nanodumbells [204], and ultrasmall nanoparticles [205, 206] (Figure 7a–f). In these studies, PET was successfully used to assess the biodistribution and tumor accumulation of radiolabeled nanoplatforms.…”