Nucleic Acid Based Fluorescent Nanothermometers

Ebrahimi, Sara; Akhlaghi, Yousef; Kompany‐Zareh, Mohsen; Rinnan, Åsmund

doi:10.1021/nn5036944

Cited by 70 publications

(63 citation statements)

References 51 publications

(87 reference statements)

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“…In line with this concept, Ebrahimi et al [34] designedabeaconl abelled with af luorophore at one end and attached to the surface of ag old nanoparticle at the other end. [34] [35] ensured quenching of the fluorophores near the gold surface.…”

Section: Molecular Beacons (Off-on)mentioning

confidence: 99%

“…In as tudy conducted by Ke et al, [10] this issue was addressed by forming ab eacon from the non-natural l-DNA backbone that prevented digestion of the stand by nucleases and other enzymatic degradationsi nside cells. In line with this concept, Ebrahimi et al [34] designedabeaconl abelled with af luorophore at one end and attached to the surface of ag old nanoparticle at the other end. This design previously introduced by Maxwelle tal.…”

Section: Molecular Beacons (Off-on)mentioning

confidence: 99%

See 1 more Smart Citation

Nanothermometry: From Microscopy to Thermal Treatments

Zhou

Sharma

Berezin³

et al. 2015

ChemPhysChem

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Measuring temperature in cells and tissues remotely, with sufficient sensitivity, and in real time presents a new paradigm in engineering, chemistry and biology. Traditional sensors, such as contact thermometers, thermocouples, and electrodes, are too large to measure the temperature with subcellular resolution and are too invasive to measure the temperature in deep tissue. The new challenge requires novel approaches in designing biocompatible temperature sensors-nanothermometers-and innovative techniques for their measurements. In the last two decades, a variety of nanothermometers whose response reflected the thermal environment within a physiological temperature range have been identified as potential sensors. This review covers the principles and aspects of nanothermometer design driven by two emerging areas: single-cell thermogenesis and image guided thermal treatments. The review highlights the current trends in nanothermometry illustrated with recent representative examples.

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Section: Molecular Beacons (Off-on)mentioning

confidence: 99%

Section: Molecular Beacons (Off-on)mentioning

confidence: 99%

Nanothermometry: From Microscopy to Thermal Treatments

Zhou

Sharma

Berezin³

et al. 2015

ChemPhysChem

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“…One possible drawback to the photothermal measurements described above is that temperature is measured on the bulk scale and not on the surface of the nanoparticle where the heat is transduced. There are thermometry techniques that can provide this local temperature information, [22][23][24] but these require more complicated sample preparation, making them more challenging to implement. Finally, the measurements described here could easily be combined with other techniques (e.g., photocatalytic degradation) 9 to assess photothermal effects on different processes.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Hybrid Fe<sub>2</sub>O<sub>3</sub>-Au Nanoparticles for Efficient Plasmonic Heating

Murph¹,

Larsen²,

Lascola³

2016

JoVE

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One of the most widely used methods for manufacturing colloidal gold nanospherical particles involves the reduction of chloroauric acid (HAuCl 4 ) to neutral gold Au(0) by reducing agents, such as sodium citrate or sodium borohydride. The extension of this method to decorate iron oxide or similar nanoparticles with gold nanoparticles to create multifunctional hybrid Fe 2 O 3 -Au nanoparticles is straightforward. This approach yields fairly good control over Au nanoparticle dimensions and loading onto Fe 2 O 3 . Additionally, the Au metal size, shape, and loading can easily be tuned by changing experimental parameters (e.g., reactant concentrations, reducing agents, surfactants, etc.). An advantage of this procedure is that the reaction can be done in air or water, and, in principle, is amenable to scaling up. The use of such optically tunable Fe 2 O 3 -Au nanoparticles for hyperthermia studies is an attractive option as it capitalizes on plasmonic heating of gold nanoparticles tuned to absorb light strongly in the VIS-NIR region. In addition to its plasmonic effects, nanoscale Au provides a unique surface for interesting chemistries and catalysis. The Fe 2 O 3 material provides additional functionality due to its magnetic property. For example, an external magnetic field could be used to collect and recycle the hybrid Fe 2 O 3 -Au nanoparticles after a catalytic experiment, or alternatively, the magnetic Fe 2 O 3 can be used for hyperthermia studies through magnetic heat induction. The photothermal experiment described in this report measures bulk temperature change and nanoparticle solution mass loss as functions of time using infrared thermocouples and a balance, respectively. The ease of sample preparation and the use of readily available equipment are distinct advantages of this technique. A caveat is that these photothermal measurements assess the bulk solution temperature and not the surface of the nanoparticle where the heat is transduced and the temperature is likely to be higher.

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“…Multivariate excitation-emission data sets have advantages over the conventional single wavelength (univariate) systems because of their rich information content [12]. AuNPs as effective fluorescence quenchers, have been used in many assays in both modified and unmodified forms [13]. In most of the recent studies, the AuNPs have been modified by the fluorophore tagged hairpin probes which are in the closed (quenched) form in the absence of the target.…”

Section: Introductionmentioning

confidence: 99%