Nucleation and crystal growth of calcium oxalate trihydrate

Gardner, G.L.

doi:10.1016/0022-0248(75)90085-8

Cited by 70 publications

(20 citation statements)

References 18 publications

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“…Thus, the final concentrations in the test were respectively 3.0 • 10 3 M and 0.5 • 10 .3 M for calcium and oxalate with a CaOx product of 1.5 • 10 6 mo121-2 and a relative supersaturation [10] of 6.17. These concentrations were chosen because they are close to physiological urinary concentrations; a pH of 5.5 was selected because it is a pH value frequently observed in the first morning urines of calcium stone-formers [2].…”

Section: Formation Of Calcium Oxalatementioning

confidence: 99%

A new approach to studying inhibitors of calcium oxalate crystal growth

et al. 1993

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The nucleation and crystal growth of calcium oxalate (CaOx) were studied at pH 5.5 using turbidimetric measurements at 620 nm of suspensions produced by mixing calcium chloride and sodium oxalate (initial conditions: Ca, 3 x 10(-3) M; Ox, 0.5 x 10(-3) M). CaOx crystallization kinetics were defined first by the induction time ti and then by the slope of turbidity as a function of time during the interval corresponding to a correlation coefficient r2 > 0.99. The technique described requires only a small amount of material, is quick, convenient, and can be used to study inhibitors of CaOx crystallization by comparing ti and the rate of crystal growth in the presence and absence of inhibitors. The effects on CaOx crystal growth of several low molecular weight compounds, i.e. di- and tricarboxylic acids, were examined. The majority of these compounds were inhibitors of crystal growth, the greatest effect being seen with citric acid (50% inhibition in the presence of 1.5 x 10(-3) M citric acid), isocitric acid (50% inhibition in the presence of 0.75 x 10(-3) M isocitric acid) and pyrophosphate (30% inhibition in presence of 0.15 x 10(-3) M pyrophosphate). The inhibitors' behaviour regarding the medium was studied without any assumptions about their possible mechanisms of action. Measurements of ionized calcium before and after the reaction, as well as the observation of crystals by scanning electron microscopy, allowed us to formulate the hypothesis that the effect of citric acid and tartaric acid can be attributed mainly to ion pairing, in contrast to that of pyrophosphate and the other carboxylic acids.

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Section: Formation Of Calcium Oxalatementioning

confidence: 99%

A new approach to studying inhibitors of calcium oxalate crystal growth

et al. 1993

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“…Three different hydrated forms of calcium oxalate are known: the monohydrate, CaC 2 O 4 ·H 2 O (whewellite), the dihydrate, CaC 2 O 4 ·2H 2 O (weddellite), and the trihydrate, CaC 2 O 4 ·3H 2 O. Thermodynamically, calcium oxalate monohydrate is the most stable phase [22,23]. Both whewellite and weddellite have been found as biominerals in a variety of organisms.…”

Section: Calcium Oxalatesmentioning

confidence: 99%

Oxalate Biominerals

and

Monje

2008

Biomineralization

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“…Metastable COT is not mentioned so often, but the work of Skrtic et al. [32] describes kinetics of spontaneous precipitation of COT and Gardner [33] published data for nucleation and crystal growth of COT. Nishikawa et al [34] synthesized single crystal of COT from dimethyl oxalate in the aqueous solution of calcium chloride (pH = 3 and 3C) and studied it by thermal analysis and single crystal X-ray structure analysis.…”

Section: Introductionmentioning

confidence: 99%

Kinetic study of dehydration of calcium oxalate trihydrate

Honcová

Svoboda

Pilný

et al. 2015

J Therm Anal Calorim

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The dehydration of calcium oxalate trihydrate was studied using DSC method and open sample crucibles. The dehydration proceeds in two steps where first two molecules of water are released around 80 °C and consequently the last molecule of water is released at a temperature around 130 °C. The kinetic analysis of overlapping peaks was done and the apparent activation energy, pre-exponential factor and kinetic exponents of kinetic model (reaction order model) were evaluated for both effects.

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Nucleation and crystal growth of calcium oxalate trihydrate

Cited by 70 publications

References 18 publications

A new approach to studying inhibitors of calcium oxalate crystal growth

A new approach to studying inhibitors of calcium oxalate crystal growth

Oxalate Biominerals

Kinetic study of dehydration of calcium oxalate trihydrate

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