Nuclear α‐actinin‐4 regulates breast cancer invasiveness and EMT
Sumon Kumar Saha,
Madhurima Sarkar,
Mahima Srivastava
et al.
Abstract:Epithelial‐to‐mesenchymal transition (EMT) is a key process where cells lose their adhesion properties and augment their invasive properties. α‐Actinin4 (ACTN4) is an actin crosslinking protein that responds to mechanical stimuli and is found to be elevated in breast cancer patients. While ACTN4 has been implicated in regulating cancer invasiveness by modulating cytoskeletal organization, its nuclear functions remain much less explored. Here we address this question by first establishing a correlation between … Show more
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