Nuclear track detectors in cellular radiation biology

Durante, Marco; Grossi, G. F.; Pugliese, M.; Gialanella, G.

doi:10.1016/1350-4487(95)00303-7

Cited by 17 publications

(6 citation statements)

References 29 publications

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“…A calibration curve was obtained for relativistic heavy ions using the same procedure adopted for light charged particles (Durante et al, 1996). Plastics exposed to unshielded beams of C (290 A MeV), Si (490 A MeV), Ti (980 A MeV), and Fe (0.5, 1, and 5 A GeV) were etched under the same conditions used for the fragmentation studies.…”

Section: Calibrationmentioning

confidence: 99%

Fragmentation studies of relativistic iron ions using plastic nuclear track detectors

Scampoli

Durante

Grossi

et al. 2005

Advances in Space Research

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Section: Calibrationmentioning

confidence: 99%

Fragmentation studies of relativistic iron ions using plastic nuclear track detectors

Scampoli

Durante

Grossi

et al. 2005

Advances in Space Research

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“…However, there are currently very few fully operational microbeams worldwide. An alternative approach, although less flexible, is to irradiate with a broad field of ␣ particles from an isotope ␣-particle source (typically 241 Am, 210 Po or 238 Pu) and determine the position of the ␣-particle traversals postirradiation using polymeric solid-state nuclear track detectors such as CR-39 or LR115 (24)(25)(26). Solid-state nuclear track detectors can also give information on the radiation field uniformity, divergence and particle fluence.…”

Section: Introductionmentioning

confidence: 99%

Production and Validation of CR-39-Based Dishes for α-Particle Radiobiological Experiments

et al. 2005

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The study of radiobiological effects induced in vitro by low fluences of alpha particles would be significantly enhanced if the precise localization of each particle track in the cell monolayer was known. From this perspective, we developed a new method based on tailor-made UV-radiation-cured CR-39, the production of which is described. Its validation both as a petri dish and as solid-state nuclear track detectors is demonstrated. With respect to the demands on solid-state nuclear track detectors in such experiments, these biologically compatible detectors have a controlled micrometric thickness that allows them to be crossed by the alpha particles. In this study, we present a method for obtaining 10-mum-thick CR-39, its chemical characterization, and its properties as a solid-state nuclear track detector under the environmental conditions of radiobiological experiments. The experimental studies performed with 3.5 MeV alpha particles show that their transmitted energy is sufficient enough to cross the entire cellular volume. Under optimal conditions, etched tracks are clearly defined 2 h after etching. Moreover, the UV-radiation-cured CR-39 represents an essentially zero background that is due to the short time between the production and use of the polymer. Under a confocal microscope, this thin solid-state nuclear track detector allows the precise localization of the impact parameter at the subcellular level.

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“…Since radiobiological effects are always described as a function of the delivered dose the quality of treatments or experiments strongly relies on the accuracy of dose measurements. Several dosimetric techniques are commonly used, either to calibrate the beam or to monitor the dose during irradiation: ionisation chambers, nuclear tracks detectors, semiconductor devices or calorimeters [1][2][3][4]. As underlined by Fukumura most of these measurements are relative and only calorimetry enables an absolute dose measurement [1].…”

Section: Introductionmentioning

confidence: 99%

Polyvinyltoluene scintillators for relative ion dosimetry: An investigation with Helium, Carbon and Neon beams

Broggio

Barillon

Jung

et al. 2007

Nuclear Instruments and Methods in Physics Research Section B:

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We present a dosimeter prototype, devoted to ion beam dosimetry, tested with Helium, Carbon and Neon ions having an equivalent range in water of 150 mm. A polyvinyltoluene based plastic scintillator is used to convert the deposited energy into scintillation, a measurement probe and a long optical fibre guide the light to a photon counting unit. Using 10-40 µm thick scintillators we show that the dosimeter gain is enough to provide useful measurements, the ion-induced scintillation can be interpreted using a model taking into account the energy deposited by secondary electrons. For a practical purpose it is shown that a linear relationship can be established between the scintillation signal and the relative dose.

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Nuclear track detectors in cellular radiation biology

Cited by 17 publications

References 29 publications

Fragmentation studies of relativistic iron ions using plastic nuclear track detectors

Fragmentation studies of relativistic iron ions using plastic nuclear track detectors

Production and Validation of CR-39-Based Dishes for α-Particle Radiobiological Experiments

Polyvinyltoluene scintillators for relative ion dosimetry: An investigation with Helium, Carbon and Neon beams

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