Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles

Li, Na; Sun, Qiaoqiao; Yu, Zhengze; Gao, Xiaonan; Pan, Wei; Wan, Xiuyan; Tang, Bo

doi:10.1021/acsnano.7b06870

Cited by 227 publications

(148 citation statements)

References 35 publications

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“…CuS@mSiO 2 core-shell nanoparticles were synthesized according to a previously reported method. 22,29 CuCl 2 (100 mM, 0.5 mL) was added to the aqueous solution of CTAB (49 mL), and aqueous Na 2 S (0.5 mL,100 mM) was added dropwise to the mixture under magnetic stirring for 15 min. After that, the solution was heated to 90°C under gentle nitrogen flow for 1 h. After CTAB-stabilized CuS nanoparticles were prepared, an extra 94 mg of CTAB (with a final concentration of 2 mg•mL −1 ) was added at 70°C under stirring.…”

Section: Synthesis Of Cus@msio 2 Nanoparticlesmentioning

confidence: 99%

Robust and Tumor-Environment-Activated DNA Cross-Linker Driving Nanoparticle Accumulation for Enhanced Therapeutics

Zhang

Fan

et al. 2020

CCS Chem

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Agglomeration of therapeutic nanoparticles in response to tumor microenvironments is a promising approach to enhance drug accumulation and improve therapeutic efficacy. Cytosine-rich DNA sequences show potential as ideal cross-linkers to drive nanoparticle agglomeration because they can sensitively respond to weak acidity and form interchain folding. However, the in vivo application of DNA is generally limited by its poor biostability; as a consequence, modifications with unprotected DNA cross-linkers can enhance the accumulation of nanoparticles twofold at the tumor site. Facing this challenge, we have designed and developed a protection and tumor-environment activation strategy to enable the in vivo application of a DNA cross-linker. Specifically, reactive oxygen species (ROS)-responsive polyethylene glycol (PEG) was modified on the nanoparticle surface together with the DNA crosslinker, which protects DNA from degradation during the blood circulation; meanwhile, when arriving at the tumor site, the nanoparticles shed the PEG shell as a response to ROS to uncover and activate the DNA cross-linkers. Using this strategy, a sevenfold enhancement in tumor accumulation was achieved owing to both superior pH sensitivity and improved stability of DNA cross-linkers. Finally, significantly improved therapeutic efficacy in in vivo anticancer treatment was realized by using this agglomeration strategy driven by protected and stimuli-activated DNA cross-linkers.

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Section: Synthesis Of Cus@msio 2 Nanoparticlesmentioning

confidence: 99%

Robust and Tumor-Environment-Activated DNA Cross-Linker Driving Nanoparticle Accumulation for Enhanced Therapeutics

Zhang

Fan

et al. 2020

CCS Chem

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“…[ 20 ] By this strategy, DOX could be delivered into nucleus and the “efflux pump” on the plasma membrane could be hopefully avoided. Arginine‐rich cell‐penetrating peptides (CPPs), particularly the TAT peptide, which originates from the HIV‐1 virus, are shown to be efficient vectors to translocate nanoparticles including mesoporous silica nanoparticles, [ 21,22 ] upconversion nanoparticles, [ 23 ] copper sulfide nanoparticles, [ 24 ] and polymer nanoparticles [ 25,26 ] into the cell nucleus. Cyclization of CPPs has been demonstrated as a new strategy to improve their ability as transmembrane carriers and nucleus targeting agents.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide‐Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple‐Drug Resistance

Donskyi

Qiao

et al. 2020

Adv Funct Materials

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Multidrug resistance resulting from a variety of defensive pathways in cancer has become a global concern with a considerable impact on the mortality associated with the failure of traditional chemotherapy. Therefore, further research and new therapies are required to overcome this challenge. In this work, a cyclic R10 peptide (cR10) is conjugated to polyglycerol‐covered nanographene oxide to engineer a nanoplatform for the surmounting of multidrug resistance. The nuclear translocation of the nanoplatform, facilitated by cR10 peptide, and subsequently, a laser‐triggered release of the loaded doxorubicin result in efficient anticancer activity confirmed by both in vitro and in vivo experiments. The synthesized nanoplatform with a combination of different features, including active nucleus‐targeting, high‐loading capacity, controlled release of cargo, and photothermal property, provides a new strategy for circumventing multidrug resistant cancers.

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“…With the development of laser-induced thermal therapy in different medical fields [1][2][3], it is of great importance to elucidate cellular effects subsequent to those thermal impacts. It is essential to understand underlying mechanisms to optimize therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%

Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study

Miura

Seifert

Rehra

et al. 2019

International Journal of Hyperthermia

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Objective/Purpose: In order to study the effects of hyperthermia and other temperature-related effects on cells and tissues, determining the precise time/temperature course is crucial. Here we present a non-contact optoacoustic technique, which provides temperatures during heating of cultured cells with scalable temporal and spatial resolution. Methods: A thulium laser (1.94 mm) with a maximum power of 15 W quickly and efficiently heats cells in a culture dish because of low penetration depth (1/e penetration depths of 78 mm) of the radiation in water. A repetitively Q-switched holmium laser (2.1 mm) is used simultaneously to probe temperatures at different locations in the dish by using the photoacoustic effect. Due to thermoelastic expansion of water, pressure waves are emitted and measured with an ultrasonic hydrophone at the side of the dish. The amplitudes of the waves are temperature dependent and can be used to calculate the temperature/time course at any location of probing. Results: We measured temperatures of up to 55 C with a heating power of 6 W after 10 s, and subsequent lateral temperature profiles over time. Within this profile, temperature fluctuations were found, likely owing to thermal convection and water circulation. By using cultured retinal pigment epithelial cells, it is shown that the probe laser pulses alone cause no biological damage, while immediate cell damage occurs when heating for 10 s at temperatures exceeding 45 C. Conclusions: This method shows great potential not only as a noninvasive, non-contact method to determine temperature/time responses of cells in culture, but also for complex tissue and other materials.

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Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles

Cited by 227 publications

References 35 publications

Robust and Tumor-Environment-Activated DNA Cross-Linker Driving Nanoparticle Accumulation for Enhanced Therapeutics

Robust and Tumor-Environment-Activated DNA Cross-Linker Driving Nanoparticle Accumulation for Enhanced Therapeutics

Graphene Oxide‐Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple‐Drug Resistance

Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study

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