Natural uranium samples have been irradiated in a neutron field generated via spallation reaction at the QUINTA target (500 kg of nat U). The dependence of the reaction rates of residual nuclei produced inside the samples on the incident deuteron energy of the maximum value of 8 GeV has been investigated. Both the activation measurement technique and the gamma-ray spectrometry have been used. A comparison with MCNPX calculation is enclosed. Nevertheless, the results are still preliminary and also need to be verified by providing further experiments.