Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function

Lamorte, Sara; Shinde, Rahul; McGaha, Tracy L.

doi:10.1016/j.mam.2021.100942

Cited by 17 publications

(13 citation statements)

References 150 publications

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“…In the non-canonical transcriptional regulatory pathway, the ligand–AhR complex heterodimerizes with partner proteins other than ARNT, for example, Krüppel-like factor 6 (KLF6) and RelB [ 92 , 93 ].…”

Section: Ahr Expression Functions and Signalingmentioning

confidence: 99%

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Grishanova

Perepechaeva

2022

IJMS

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The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a ligand-activated transcription factor necessary for the launch of transcriptional responses important in health and disease. In past decades, evidence has accumulated that AhR is associated with the cellular response to oxidative stress, and this property of AhR must be taken into account during investigations into a mechanism of action of xenobiotics that is able to activate AhR or that is susceptible to metabolic activation by enzymes encoded by the genes that are under the control of AhR. In this review, we examine various mechanisms by which AhR takes part in the oxidative-stress response, including antioxidant and prooxidant enzymes and cytochrome P450. We also show that AhR, as a participant in the redox balance and as a modulator of redox signals, is being increasingly studied as a target for a new class of therapeutic compounds and as an explanation for the pathogenesis of some disorders.

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Section: Ahr Expression Functions and Signalingmentioning

confidence: 99%

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Grishanova

Perepechaeva

2022

IJMS

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“…AhR ligands (101). AhR is widely expressed in almost all cell types; in particular, both innate and adaptive immune cells express AhR, suggesting its potential broad-range effects on host immunity (102). AhR is present in the cytoplasm and is activated upon binding to a ligand.…”

Section: Ahr Signaling Pathwaymentioning

confidence: 99%

“…Particularly, bacterial pigment proteins such as phenazine produced by P. aeruginosa and 1,4-naphthoquinone phthiochol (Pht) produced by Mtb have been identified as bacterial-derived AhR ligands ( 101 ). AhR is widely expressed in almost all cell types; in particular, both innate and adaptive immune cells express AhR, suggesting its potential broad-range effects on host immunity ( 102 ). AhR is present in the cytoplasm and is activated upon binding to a ligand.…”

Section: Antibiotics Can Affect Host Immunity and Influence Clinical Outcomesmentioning

confidence: 99%

“…AhR is present in the cytoplasm and is activated upon binding to a ligand. Activated AhR binds to the AhR nuclear translocator (ARNT) and regulates the transcription of several target genes, including cytochrome P450 monooxygenases ( CYP1A1 and CYP1B1 ), AhR inhibitor, and pro-inflammatory cytokines ( 102 ) ( Figure 2 ).…”

Section: Antibiotics Can Affect Host Immunity and Influence Clinical Outcomesmentioning

confidence: 99%

“…Ligand-activated AhR translocates to the nucleus from the cytosol and induces immunosuppressive or pro-inflammatory downstream effects depending on the ligand property ( 102 ). Further, AhR can modulate macrophage immune response.…”

Section: Antibiotics Can Affect Host Immunity and Influence Clinical Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Understanding the Reciprocal Interplay Between Antibiotics and Host Immune System: How Can We Improve the Anti-Mycobacterial Activity of Current Drugs to Better Control Tuberculosis?

et al. 2021

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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, remains a global health threat despite recent advances and insights into host-pathogen interactions and the identification of diverse pathways that may be novel therapeutic targets for TB treatment. In addition, the emergence and spread of multidrug-resistant Mtb strains led to a low success rate of TB treatments. Thus, novel strategies involving the host immune system that boost the effectiveness of existing antibiotics have been recently suggested to better control TB. However, the lack of comprehensive understanding of the immunomodulatory effects of anti-TB drugs, including first-line drugs and newly introduced antibiotics, on bystander and effector immune cells curtailed the development of effective therapeutic strategies to combat Mtb infection. In this review, we focus on the influence of host immune-mediated stresses, such as lysosomal activation, metabolic changes, oxidative stress, mitochondrial damage, and immune mediators, on the activities of anti-TB drugs. In addition, we discuss how anti-TB drugs facilitate the generation of Mtb populations that are resistant to host immune response or disrupt host immunity. Thus, further understanding the interplay between anti-TB drugs and host immune responses may enhance effective host antimicrobial activities and prevent Mtb tolerance to antibiotic and immune attacks. Finally, this review highlights novel adjunctive therapeutic approaches against Mtb infection for better disease outcomes, shorter treatment duration, and improved treatment efficacy based on reciprocal interactions between current TB antibiotics and host immune cells.

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Recent progress in neonatal hyperoxic lung injury

Rao,

Zhou,

Chen

et al. 2024

Pediatric Pulmonology

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With the progress in neonatal intensive care, there has been an increase in the survival rates of premature infants. However, this has also led to an increased incidence of neonatal hyperoxia lung injury and bronchopulmonary dysplasia (BPD), whose pathogenesis is believed to be influenced by various prenatal and postnatal factors, although the exact mechanisms remain unclear. Recent studies suggest that multiple mechanisms might be involved in neonatal hyperoxic lung injury and BPD, with sex also possibly playing an important role, and numerous drugs have been proposed and shown promise for improving the treatment outcomes of hyperoxic lung injury. Therefore, this paper aims to analyze and summarize sex differences in neonatal hyperoxic lung injury, potential pathogenesis and treatment progress to provide new ideas for basic and clinical research in this field.

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Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function

Cited by 17 publications

References 150 publications

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Understanding the Reciprocal Interplay Between Antibiotics and Host Immune System: How Can We Improve the Anti-Mycobacterial Activity of Current Drugs to Better Control Tuberculosis?

Recent progress in neonatal hyperoxic lung injury

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