Nuclear receptor BgFTZ‐F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect <i>Blattella germanica</i>

Cruz, Josefa; Nieva, Claudia; Mané-Padrós, Daniel; Martin, David L.; Bellés, Xavier

doi:10.1002/dvdy.21728

Cited by 63 publications

(73 citation statements)

References 45 publications

(74 reference statements)

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“…This specific timing of induction has been observed, not only in D. melanogaster, but in all insects investigated so far, M. sexta [75], B. mori [86], A. aegypti [87] and B. germanica [68], and is the result of the previously described cross-regulatory interplay between E75, HR3 and HR4 (Figure 3.3). During post-embryonic development FTZ-F1 is necessary for molting in D. melanogaster, T. castaneum, and B. germanica [85,68,47]. Furthermore, during the prepupal stage of D. melanogaster, βFTZ-F1 plays a crucial role as a competence factor for stage-specific responses to a second 20E pulse that triggers the onset of pupal development (Figure 3.2).…”

Section: Ftz-f1 (Nr5a3)mentioning

confidence: 75%

“…The role as a competence factor for stage-specific transcriptional responses to 20E is conserved in the holometabolous insects since it has been also reported during the previtellogenic-vitellogenic transition in the dipteran A. aegypti [87,89,90]. Conversely, in more primitive insects, such as B. germanica, FTZ-F1 does not play any role in transcriptional competence, but controls the timing of the onset of ecdysteroid production during the intermolt periods [68]. This function could represent an ancestral role of FTZ-F1 during post-embryonic development that has been probably lost in more derived insects.…”

Section: Ftz-f1 (Nr5a3)mentioning

confidence: 89%

“…In all these stages, βFTZ-F1 is expressed as the ecdysteroid titer declines, just before each developmental transition (Figure 3.2) [85,18]. This specific timing of induction has been observed, not only in D. melanogaster, but in all insects investigated so far, M. sexta [75], B. mori [86], A. aegypti [87] and B. germanica [68], and is the result of the previously described cross-regulatory interplay between E75, HR3 and HR4 (Figure 3.3). During post-embryonic development FTZ-F1 is necessary for molting in D. melanogaster, T. castaneum, and B. germanica [85,68,47].…”

Section: Ftz-f1 (Nr5a3)mentioning

confidence: 95%

“…From a mechanistic point of view, it is important to note that most of the HR3 mutant/knockdown phenotypes are due to the absence of another important NR, FTZ-F1, a direct target of HR3 [67], [65,68]. However, as it has been previously described, the HR3-dependent induction of FTZ-F1 is negatively regulated by E75, hence defining a key 20E-dependent cross-regulatory network [48].…”

Section: Hr3 (Nr1f4)mentioning

confidence: 98%

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Functions of Nuclear Receptors in Insect Development

MartÍn

2010

Nuclear Receptors

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Abstract:Nuclear hormone receptors form a large family of ligand-activated transcription factors that regulate the transcription of target genes involved in a variety of important biological processes in animal development. Intense research over the past years has led to the characterization of the complete set of nuclear hormone receptors in several invertebrate genomes, including those of six insect species. In these organisms, extensive studies have defined critical roles for nuclear hormone receptors in controlling embryonic development, molting, metamorphosis, reproduction and metabolism. In this chapter, I review our understanding of the biological functions of all insect nuclear hormone receptors.

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Section: Ftz-f1 (Nr5a3)mentioning

confidence: 75%

Section: Ftz-f1 (Nr5a3)mentioning

confidence: 89%

Section: Ftz-f1 (Nr5a3)mentioning

confidence: 95%

Section: Hr3 (Nr1f4)mentioning

confidence: 98%

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Functions of Nuclear Receptors in Insect Development

MartÍn

2010

Nuclear Receptors

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“…In the fruit fly Drosophila melanogaster, molting and metamorphosis-inducing factor 20 hydroxyecdysone (20E) led to the expression of EcR, USP, HR3, HR4, HR78, E75, E78, and FTZ-F1 genes (Sullivan and Thummel, 2003). In early metamorphosis of the hemimetabolous insect (Blattella germanica), RNAi injection of EcR, USP, E75, HR3, and FTZ-F1 caused stage-specific developmental arrest (Cruz et al, 2008). To date, ecdysteroid signaling pathway-related genes have a role in both reproduction and development of ecdysozoa (Oro et al, 1992;Fahrbach et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus

et al. 2016

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Origin and Evolution of Insect Metamorphosis

Bellés

2011

Encyclopedia of Life Sciences

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Brazilian livestock stands out in the international scenario representing the largest cattle herd in the world. In this context, the costs of livestock activities are high, especially the investment in animal health products, such as antiparasites, in order to control the damages associated with the deleterious effects of the parasites, with greater relevance for tick infestations and Haematobia irritans, known as fly of the horns. Currently, the traditional control of this parasite uses indiscriminate conventional pesticides with broad spectrum, exposing animals, living beings and the environment to toxic risks, accelerating the resistance process. However, Piriproxifem belonging to the class of insect growth inhibitors (IGR), is a biorational parasiticide, with selective action mechanism for insects, being highly safe for the control of the immature forms of H.irritans. The oral efficacy of Piriproxifem allows the development of an oral dosage form, appropriating the pharmaceutical technology to corroborate strategies for the control of the asset release system, such as the use of polymer matrices impregnated, in order to increase the residence time of the drug in rumem, and consequently prolong the time of action of the insect control. The main purpose of the controlled release system is to increase the safety of the product and to extend the pharmacological action when associated to the polymers PEG, PCL e PLGA, promoting the gradual dissolution of the drug. The formulation was physicochemically characterized by infra-red spectroscopy (FTIR), morphological assays by scanning electron microscopy (SEM) and thermal analysis by thermogravimetric (TGA) assays. The methodologies used for the development of the release system and the in vitro dissolution profile were evaluated. The results demonstrated that it was possible to develop a controlled release formulation containing pyriproxyfen by the evaluation of the dissolution kinetic study, and the incorporation methodologies did not differ significantly in the release profile. The spectral analyzes elucidated the structures and their characteristic attributions of each polymer. The highest volumetric fraction found in the micrographs of the PCL, PLGA and PEG polymers was 96.02%, 76.24% and 86.88% represented by the dipped incorporation method, whereas the lowest volumetric fraction was 94, 85%, 75.84% and 84.84% corresponding to the impregnated method. TGA and DTG demonstrated the results of initial mass loss (6.9 ± 0.02), and it was possible to evaluate the degradation temperature of each formulation.

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Nuclear receptor BgFTZ‐F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect Blattella germanica

Cited by 63 publications

References 45 publications

Functions of Nuclear Receptors in Insect Development

Functions of Nuclear Receptors in Insect Development

BDE-47 causes developmental retardation with down-regulated expression profiles of ecdysteroid signaling pathway-involved nuclear receptor (NR) genes in the copepod Tigriopus japonicus

Origin and Evolution of Insect Metamorphosis

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