Nuclear Pore Complex

The discovery of a Werner helicase interacting protein (WHIP) association with the nuclear pore complex

“…NPCs allow passive diffusion of ions and small molecules and facilitate receptor-mediated transport of signal bearing cargoes, such as proteins, RNAs and ribonucleoprotein particles. [1][2][3][4][5] Overall the NPC is composed of about 30 proteins, 6,7 termed nucleoporins (Nups) that are organized into a pseudo-symmetric structure with a two-fold plane quasi-parallel to the nuclear envelope and an eight-fold axis of symmetry across the nucleocytoplasmic axis. Most of the Nups are part of a symmetric core structure and therefore occur in at least 16 copies per NPC (e.g., Nup107, Nup133).…”