volume 10, issue 10, P2911-2934 2018
DOI: 10.18632/aging.101599
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Francesca Casciaro, Francesca Beretti, Manuela Zavatti, James A. McCubrey, Stefano Ratti, Sandra Marmiroli, Matilde Y. Follo, Tullia Maraldi

Abstract: Mesenchymal stem cells have emerged as an important tool that can be used for tissue regeneration thanks to their easy preparation, differentiation potential and immunomodulatory activity. However, an extensive culture of stem cells in vitro prior to clinical use can lead to oxidative stress that can modulate different stem cells properties, such as self-renewal, proliferation, differentiation and senescence. The aim of this study was to investigate the aging process occurring during in vitro expansion of stem…

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