Nuclear Molecular Imaging of Cardiac Remodeling after Myocardial Infarction

Varasteh, Zohreh; Rischpler, Christoph

doi:10.3390/ph15020183

Cited by 5 publications

(4 citation statements)

References 76 publications

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“…However, other microvascular heart conditions, such as dysregulated stress adaptation and cardiac remodeling, can also lead to a positive thallium stress test and affect the patient's quality of life. Advanced nuclear molecular imaging techniques have been developed to detect molecules along the pathophysiological pathways of cardiac remodeling [27][28][29]. However, these techniques require advanced radiopharmaceuticals or modalities.…”

Section: Discussionmentioning

confidence: 99%

Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects

et al. 2023

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Stress-induced myocardial perfusion defects found in dipyridamole–thallium-201 single-photon emission computed tomography imaging may indicate vascular perfusion abnormalities and risk of obstructive or nonobstructive coronary heart disease. Besides nuclear imaging and subsequent coronary angiography (CAG), no blood test can indicate whether dysregulated homeostasis is associated with stress-induced myocardial perfusion defects. This study investigated the expression signature of long noncoding RNAs (lncRNAs) and genes involved in vascular inflammation and stress response in the blood of patients with stress-induced myocardial perfusion abnormalities (n = 27). The results revealed an expression signature consisting of the upregulation of RMRP (p < 0.01) and downregulations of THRIL (p < 0.01) and HIF1A (p < 0.01) among patients with a positive thallium stress test and no significant coronary artery stenosis within 6 months after baseline treatment. We developed a scoring system based on the expression signatures of RMRP, MIAT, NTT, MALAT1, HSPA1A, and NLRP3 to predict the need for further CAG among patients with moderate-to-significant stress-induced myocardial perfusion defects (area under the receiver operating characteristic curve = 0.963). Therefore, we identified a dysregulated expression profile of lncRNA-based genes in the blood that could be valuable for the early detection of vascular homeostasis imbalance and personalized therapy.

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Section: Discussionmentioning

confidence: 99%

Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects

et al. 2023

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“…Cardiac remodeling, a process associated with conditions such as hypertension, MI and valvular disease, involves changes in the heart’s structure and function in response to chronic stress and injury [ 80 , 81 , 82 ]. Oxidative stress is a key regulator of pressure overload induced cardiac remodeling [ 83 ].…”

Section: Research Progress In Gpx3 and Non-neoplastic Diseasesmentioning

confidence: 99%

Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Zhang,

Liao,

Lin

et al. 2024

Biomolecules

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Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play pivotal roles in various physiological processes. Disruptions in the balance between ROS levels and the body’s antioxidant defenses can lead to the development of numerous diseases. Glutathione peroxidase 3 (GPX3), a key component of the body’s antioxidant system, is an oxidoreductase enzyme. GPX3 mitigates oxidative damage by catalyzing the conversion of hydrogen peroxide into water. Beyond its antioxidant function, GPX3 is vital in regulating metabolism, modulating cell growth, inducing apoptosis and facilitating signal transduction. It also serves as a significant tumor suppressor in various cancers. Recent studies have revealed aberrant expression of GPX3 in several non-neoplastic diseases, associating it with multiple pathological processes. This review synthesizes the current understanding of GPX3 expression and regulation, highlighting its extensive roles in noncancerous diseases. Additionally, this paper evaluates the potential of GPX3 as a diagnostic biomarker and explores emerging therapeutic strategies targeting this enzyme, offering potential avenues for future clinical treatment of non-neoplastic conditions.

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“…Although imaging of FAP focuses on the fibroblast and currently enjoys widespread attention because of its success in oncology, a range of tracers has been introduced that target alternative pathways or molecular structures involved in tissue fibrosis. An extensive review of ECM molecular imaging has, for example, been published by De Haas et al (69), and a review specifically focusing on molecular imaging of cardiac remodeling after AMI has been published by Varasteh et al (70). Of note, most original work in this area is preclinical, and when compared with FAPI tracers, translation to humans is not as extensive.…”

Section: Radionuclide Imaging Of Other Fibrosis-associated Targetsmentioning

confidence: 99%

Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

Bengel,

Diekmann,

Hess

et al. 2023

J Nucl Med

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Myocardial fibrosis is a major contributor to the development and progression of heart failure. Significant progress in the understanding of its pathobiology has led to the introduction and preclinical testing of multiple highly specific antifibrotic therapies. Because the mechanisms of fibrosis are highly dynamic, and because the involved cell populations are heterogeneous and plastic, there is increasing emphasis that any therapy directed specifically against myocardial fibrosis will require personalization and guidance by equally specific diagnostic testing for successful clinical translation. Noninvasive imaging techniques have undergone significant progress and provide increasingly specific information about the quantity, quality, and activity of myocardial fibrosis. Cardiac MRI can precisely map the extracellular space of the myocardium, whereas nuclear imaging characterizes activated fibroblasts and immune cells as the cellular components contributing to fibrosis. Existing techniques may be used in complementarity to provide the imaging biomarkers needed for the success of novel targeted therapies. This review provides a road map on how progress in basic fibrosis research, antifibrotic drug development, and high-end noninvasive imaging may come together to facilitate the success of fibrosis-directed cardiovascular medicine.

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Nuclear Molecular Imaging of Cardiac Remodeling after Myocardial Infarction

Cited by 5 publications

References 76 publications

Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects

Association of Long Noncoding RNA Expression Signatures with Stress-Induced Myocardial Perfusion Defects

Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases

Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

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