Nuclear Medicine in Neurodegenerative Disorders

Asenbaum, S.

doi:10.1046/j.1617-0830.6.s1.3.x

Cited by 1 publication

(1 citation statement)

References 67 publications

(81 reference statements)

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“…SPECT imaging of dopamine transporter with 99m Tc-TRODAT-1 (TRODAT-1) has been proposed to be a valuable and feasible means for the diagnosis of Parkinson's disease and dementia with Lewy bodies (DLB) [1–5]. The specific tracer, TRODAT-1, a radiolabeled tropane that binds dopamine transporters, allows in vivo assessment of the presynaptic dopaminergic neuron activity inside the striatum [3, 6].…”

Section: Introductionmentioning

confidence: 99%

Segmentation of the Striatum from MR Brain Images to Calculate the -TRODAT-1 Binding Ratio in SPECT Images

Jiang

Chang

Huang

et al. 2013

Computational and Mathematical Methods in Medicine

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Quantification of regional 99mTc-TRODAT-1 binding ratio in the striatum regions in SPECT images is essential for differential diagnosis between Alzheimer's and Parkinson's diseases. Defining the region of the striatum in the SPECT image is the first step toward success in the quantification of the TRODAT-1 binding ratio. However, because SPECT images reveal insufficient information regarding the anatomical structure of the brain, correct delineation of the striatum directly from the SPECT image is almost impossible. We present a method integrating the active contour model and the hybrid registration technique to extract regions from MR T1-weighted images and map them into the corresponding SPECT images. Results from three normal subjects suggest that the segmentation accuracy using the proposed method was compatible with the expert decision but has a higher efficiency and reproducibility than manual delineation. The binding ratio derived by this method correlated well (R 2 = 0.76) with those values calculated by commercial software, suggesting the feasibility of the proposed method.

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Section: Introductionmentioning

confidence: 99%