Nuclear Magnetic Resonance Tomographic Imaging in Liver Disease.

Smith, Francis W.; Mallard, J. R.; Hutchison, J.M.S.; Reid, Anne

doi:10.1097/00004728-198202000-00071

Cited by 5 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some reports [2,5,10,11] have suggested that MRI may not be sufficiently sensitive in the evaluation of diffuse fatty liver. Wenker et al [13] presented a case in which MRI was as sensitive as CT and ultrasound in demonstrating FFLC.…”

Section: Discussionmentioning

confidence: 99%

Focal fatty liver change in a 12-year-old Japanese boy

Igarashi¹,

Akiyama²,

Nakamura

et al. 1994

Eur J Pediatr

View full text Add to dashboard Cite

We describe a 12-year-old patient with focal fatty liver change (FFLC). The lesion was incidentally detected by ultrasonography which showed a circumscribed hyperechoic lesion measuring approximately 6 x 4 cm. The lesion was also examined by CT and MRI. Histologically, the lesion corresponded to a focal area of lipid-laden hepatocytes. FFLC has been delineated as a disease entity in adults. As shown by this report, it may also occur in children. There was no associated clinical morbidity and the lesion was incidentally detected by modern imaging techniques. The aetiology and pathogenesis are unknown. The significance of focal fatty lesions is their differentiation from other focal lesions such as hepatic cell carcinomas, metastatic tumours, abscess and benign tumours including lipoma, haemangioma and angiomyolipoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Focal fatty liver change in a 12-year-old Japanese boy

Igarashi¹,

Akiyama²,

Nakamura

et al. 1994

Eur J Pediatr

View full text Add to dashboard Cite

show abstract

“…In many organs and regions it is con sidered superior to or at least equal to other forms of tomography based on X-ray or ultra sound [1][2][3][4][5]. Renal MRI has been successfully used to differentiate normal from pathological renal tissue [6][7][8]. Proton nuclear magnetic res onance spectroscopy (NMR) imaging of the kidney was used with some success in the dif ferentiation of insufficiency after kidney trans plantation.…”

Section: Introductionmentioning

confidence: 99%

Renal Proton Magnetic Resonance in Experimental Acute Renal Failure in Rats

Iaina

Weininger²,

Abrashkin³

et al. 1989

Kidney Blood Press Res

View full text Add to dashboard Cite

Cortical, medullary and papillary T₁ and T₂ water proton relaxation times were measured at 37°C, 20 MHz. The measurements were made using kidneys from rats affected by many forms of experimental acute renal failure (ARF), namely acute hemorrhagic hypovolemia, angiotensin II administration, antidiuretic hormone (ADH) administration, glycerol, and other nephrotoxins (gentamicin, cisplatinum, cyclosporine), renal artery occlusion for different periods of time, and ureteral ligation. From the T_1· and PW (percent tissue water content) the bound water (FB) and HF (percent water bound/g solid) were calculated according to a fast proton diffusion model. In most experimental models studied, the experiments were repeated following paramagnetic enhancement with GdDTPA administration (70 mmol/kg BW). By profiling the deviations from normal, it was possible to differentiate the ischemic (shortened T_1; prolonged T₂), obstructive (very high T_1· and T₂ in both cortex and medulla) and nephrotoxic (prolonged T₂) forms of ARF Significant changes in free/bound water compartments occurred, though their biological significance is unknown. T_1· and T₂ ratios before and after paramagnetic enhancement correlated well with estimates of glomerular filtration rate. In the first minutes following acute hemorrhagic hypovolemia, the intrarenal water distribution remained unchanged. After GdDTPA significant water proton T₁ and T₂ changes characterized the immediate posthemor-rhagic state similar to the effect of ADH.

show abstract

“…During this time it has been shown to be of diagnostic value in studying the brain [1], abdomen [14,15], and in pediatric practice [11,8], more recently its potential for examining the normal fetus in-utero has been demonstrated [7,16,17] as well as abnormal pregnancy [18].…”

Section: Introductionmentioning

confidence: 99%