Nuclear Magnetic Resonance Tomographic Imaging in Liver Disease

Smith, F. W.; Mallard, J. R.; Reid, Anne; Hutchison, J.M.S.

doi:10.1016/s0140-6736(81)91731-1

Cited by 126 publications

(28 citation statements)

References 15 publications

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“…The earliest work suggesting the concept that T1 relates to the degree of liver fibrosis was reported in 1981 [21] but subsequent studies failed to show any clear relationship [22,23]. Recently, with the development of robust single breath-hold T1 mapping techniques, interest in the field has increased again [24,25].…”

Section: Discussionmentioning

confidence: 99%

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

Banerjee

Pavlides

Tunnicliffe

et al. 2014

Journal of Hepatology

402

429

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Background & AimsWith the increasing prevalence of liver disease worldwide, there is an urgent clinical need for reliable methods to diagnose and stage liver pathology. Liver biopsy, the current gold standard, is invasive and limited by sampling and observer dependent variability. In this study, we aimed to assess the diagnostic accuracy of a novel magnetic resonance protocol for liver tissue characterisation.MethodsWe conducted a prospective study comparing our magnetic resonance technique against liver biopsy. The individual components of the scanning protocol were T1 mapping, proton spectroscopy and T2⁎ mapping, which quantified liver fibrosis, steatosis and haemosiderosis, respectively. Unselected adult patients referred for liver biopsy as part of their routine care were recruited. Scans performed prior to liver biopsy were analysed by physicians blinded to the histology results. The associations between magnetic resonance and histology variables were assessed. Receiver-operating characteristic analyses were also carried out.ResultsPaired magnetic resonance and biopsy data were obtained in 79 patients. Magnetic resonance measures correlated strongly with histology (rs = 0.68 p <0.0001 for fibrosis; rs = 0.89 p <0.001 for steatosis; rs = −0.69 p <0.0001 for haemosiderosis). The area under the receiver operating characteristic curve was 0.94, 0.93, and 0.94 for the diagnosis of any degree of fibrosis, steatosis and haemosiderosis respectively.ConclusionThe novel scanning method described here provides high diagnostic accuracy for the assessment of liver fibrosis, steatosis and haemosiderosis and could potentially replace liver biopsy for many indications. This is the first demonstration of a non-invasive test to differentiate early stages of fibrosis from normal liver.

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Section: Discussionmentioning

confidence: 99%

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

Banerjee

Pavlides

Tunnicliffe

et al. 2014

Journal of Hepatology

402

429

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“…It has been suggested that the increase of the hepatic proton spin-lattice relaxation time (TI) could be an indicator of liver fibrosis in man (5)(6)(7). Goldberg et al (8) did not find any significant change in hepatic TI and Tz in rats treated with thioacetamide intraperitoneally for 8 weeks, an experimental model that yields liver fibrosis in an unpredictable way.…”

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confidence: 99%

Is the magnetic resonance imaging proton spin-lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?

et al. 1988

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During the development of liver fibrosis in rats by an individual dose-titrated CCl4 administration, hepatic proton spin-lattice relaxation time (T1) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl4 treatment, T1 increased significantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T1 represents drug-induced edema and that hepatic T1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo.

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“…The instrumentation required is similar in complexity and cost to that of x-ray CT, and the broad range and flexibility of NMR suggest that it may have profound advan- 5 FEBRUARY 1982 tages for medical diagnostic imaging by use of protons and other nuclei for noninvasive measurements of tissue composition (77,78).…”

Section: Future Medical Uses Of Nuclearmentioning

confidence: 99%

Positron Tomography and Nuclear Magnetic Resonance Imaging

Brownell

Budinger²,

Lauterbur

et al. 1982

Science

100

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Noninvasive imaging methods for medical diagnosis and biological investigations, have evolved from qualitative radiological techniques to quantitative methods of measuring biochemical and physiological processes in human body. In particular, new developments in emission tomography, nuclear magnetic resonance imaging, and in vivo spectroscopy offer new horizons for medical research and clinical activities. These methods and their potentials are reviewed and contrasted.

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Nuclear Magnetic Resonance Tomographic Imaging in Liver Disease

Cited by 126 publications

References 15 publications

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

Is the magnetic resonance imaging proton spin-lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?

Positron Tomography and Nuclear Magnetic Resonance Imaging

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