Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis

Meshitsuka, Shunsuke; Yamazaki, Etsuko; Inoue, Masakatsu; Hagino, Hiroshi; Teshima, Ryota; Yamamoto, Kichizo

doi:10.1016/s0009-8981(98)00200-9

Cited by 33 publications

(55 citation statements)

References 11 publications

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“…Inhibitors of pyruvate metabolism downregulate infl ammation ( 11 ). Proton (hydrogen 1 [ 1 H]) nuclear MR studies have also demonstrated elevated lactate levels in the synovial fl uid and synovium of patients with rheumatoid arthritis and in rodent models of infl ammatory arthritis (12)(13)(14)(15).…”

Section: Animal Preparationmentioning

confidence: 99%

“…The goal of this preliminary study was to test whether MR spectroscopic imaging with hyperpolarized 13 C-labeled pyruvate can provide an objective and quantitative measure of arthritis, which may eventually be helpful in clinical decision making and treatment planning. Alterations in pyruvate metabolism may be interrogated by injecting a bolus of hyperpolarized 13 C-pyruvate-a nontoxic, easily polarized, and rapidly metabolized substrate ( 16 ).…”

Section: Animal Preparationmentioning

confidence: 99%

Section: Animal Preparationmentioning

confidence: 99%

“…Alterations in pyruvate metabolism may be interrogated by injecting a bolus of hyperpolarized 13 C-pyruvate-a nontoxic, easily polarized, and rapidly metabolized substrate ( 16 ). Currently, no previous studies have examined the feasibility of using hyperpolarized 13 C-labeled pyruvate to detect infl ammation. We hypothesize that it may be possible to detect the presence of infl ammation by depicting alterations in the conversion of hyperpolarized 13 C-pyruvate to lactate at 13 C MR spectroscopy.…”

Section: Animal Preparationmentioning

confidence: 99%

“…EXPERIMENTAL STUDIES: Detection of Infl ammatory Arthritis with 13 C-Pyurvate MacKenzie et al 13 C MR spectroscopy and hyperpolarized 13 C-pyruvate.…”

mentioning

confidence: 99%

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Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

MacKenzie¹,

Yen²,

Mayer³

et al. 2011

Radiology

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Purpose:To examine the feasibility of using magnetic resonance (MR) spectroscopy with hyperpolarized carbon 13 ( 13 C)-labeled pyruvate to detect infl ammation. Materials and Methods:The animal care and use committee approved all work with animals. Arthritis was induced in the right hind paw of six rats; the left hind paw served as an internal control. The lactate dehydrogenase-catalyzed conversion of pyruvate to lactate was measured in infl amed and control paws by using 13 C MR spectroscopy. Clinical and histologic data were obtained to confi rm the presence and severity of arthritis. Hyperpolarized 13 C-pyruvate was intravenously injected into the rats before simultaneous imaging of both paws with 13 C MR spectroscopy. The Wilcoxon signed rank test was used to test for differences in metabolites between the control and arthritic paws.

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Section: Animal Preparationmentioning

confidence: 99%

Section: Animal Preparationmentioning

confidence: 99%

Section: Animal Preparationmentioning

confidence: 99%

Section: Animal Preparationmentioning

confidence: 99%

“…EXPERIMENTAL STUDIES: Detection of Infl ammatory Arthritis with 13 C-Pyurvate MacKenzie et al 13 C MR spectroscopy and hyperpolarized 13 C-pyruvate.…”

mentioning

confidence: 99%

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Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

MacKenzie¹,

Yen²,

Mayer³

et al. 2011

Radiology

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Metabolomics Approach in Allergic and Rheumatic Diseases

Casadei

Valerio

Priori

et al. 2014

Curr Allergy Asthma Rep

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Metabolomics is the analysis of the concentration profiles of low molecular weight compounds present in biological fluids. Metabolites are nonpeptide molecules representing the end products of cellular activity. Therefore, changes in metabolite concentrations reveal the range of biochemical effects induced by a disease or its therapeutic intervention. Metabolomics has recently become feasible with the accessibility of new technologies, including mass spectrometry and high-resolution proton nuclear magnetic resonance, and has already been applied to several disorders. Indeed, it has the advantage of being a nontargeted approach for identifying potential biomarkers, which means that it does not require a preliminary knowledge of the substances to be studied. In this review, we summarize the main studies in which metabolomic approach was used in some allergic (asthma, atopic dermatitis) and rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus) to explore the feasibility of this technique as a novel diagnostic tool in these complex disorders.

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Metabolomics in rheumatic diseases: The potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy

Priori

Scrivo

Brandt

et al. 2013

Autoimmunity Reviews

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Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis

Cited by 33 publications

References 11 publications

Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

Metabolomics Approach in Allergic and Rheumatic Diseases

Metabolomics in rheumatic diseases: The potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy

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Nuclear magnetic resonance studies of synovial fluids from patients with rheumatoid arthritis and osteoarthritis

Cited by 33 publications

References 11 publications

Detection of Inflammatory Arthritis by Using Hyperpolarized13C-Pyruvate with MR Imaging and Spectroscopy

Detection of Inflammatory Arthritis by Using Hyperpolarized13C-Pyruvate with MR Imaging and Spectroscopy

Metabolomics Approach in Allergic and Rheumatic Diseases

Metabolomics in rheumatic diseases: The potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy

Contact Info

Product

Resources

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Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy

Detection of Inflammatory Arthritis by Using Hyperpolarized¹³C-Pyruvate with MR Imaging and Spectroscopy