Nuclear Magnetic Resonance of Laser-Polarized Noble Gases in Molecules, Materials, and Organisms

Goodson, Boyd M.

doi:10.1006/jmre.2001.2341

Cited by 415 publications

(254 citation statements)

References 236 publications

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“…This technique adapts particularly well to laser-polarized Xe-129 NMR, not only because the highly polarized and chemically inert noble gas atom with long T 1 relaxation time is tailored for the role of an effective transport medium for spin polarization, but also because it provides a wealth of NMR-based physiochemical and biomedical information [7][8][9][10][11][12][13]. Thus, Xe-129 is a powerful sensor of its local environment and can retain information about that environment for a sufficient amount of time during transport.…”

Section: Introductionmentioning

confidence: 99%

Remotely detected high-field MRI of porous samples

Seeley

Han

Pines

2004

Journal of Magnetic Resonance

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Remote detection of NMR is a novel technique in which an NMR-active sensor surveys an environment of interest and retains memory of that environment to be recovered at a later time in a different location. The NMR or MRI information about the sensor nucleus is encoded and stored as spin polarization at the first location and subsequently moved to a different physical location for optimized detection. A dedicated probe incorporating two separate radio frequency (RF) -circuits was built for this purpose. The encoding solenoid coil was large enough to fit around the bulky sample matrix, while the smaller detection solenoid coil had not only a higher quality factor but also an enhanced filling factor since the coil volume comprised purely the sensor nuclei. We obtained two-dimensional (2D) void space images of two model porous samples with resolution less than 1.4 mm 2 . The remotely-reconstructed images demonstrate the ability to determine fine structure with image quality superior to their directly detected counterparts and show the great potential of NMR remote detection for imaging applications that suffer from low sensitivity due to low concentrations and filling factor.

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Section: Introductionmentioning

confidence: 99%

Remotely detected high-field MRI of porous samples

Seeley

Han

Pines

2004

Journal of Magnetic Resonance

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“…(156) Researchers discovered the potential of these noble, stable gas isotopes as a side-effect to nuclear physics experiments, which required hyperpolarization of 3-He to produce neutron mirrors. Hyperpolarization is a process whereby the atoms are brought to a higher energy level by introduction of laser light at the appropriate bandwidth.…”

Section: Hyperpolarized Gas Imagingmentioning

confidence: 99%

Functional Imaging: CT and MRI

Beek

Hoffman

2008

Clinics in Chest Medicine

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Synopsis-Numerous imaging techniques permit evaluation of regional pulmonary function. Contrast-enhanced CT methods now allow assessment of vasculature and lung perfusion. Techniques using spirometric controlled MDCT allow for quantification of presence and distribution of parenchymal and airway pathology, Xenon gas can be employed to assess regional ventilation of the lungs and rapid bolus injections of iodinated contrast agent can provide quantitative measure of regional parenchymal perfusion. Advances in magnetic resonance imaging (MRI) of the lung include gadolinium-enhanced perfusion imaging and hyperpolarized helium imaging, which can allow imaging of pulmonary ventilation and .measurement of the size of emphysematous spaces.

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“…In recent years, it was shown that hyperpolarized xenon is an exquisitely sensitive sensor of its direct environment [1]. Applications of xenon as a probe typically require it to be either bound to, adsorbed [2,3], or in sufficient proximity [4,5] to the analyte.…”

Section: Introductionmentioning

confidence: 99%

NMR detection using laser-polarized xenon as a dipolar sensor

Granwehr

Urban

Trabesinger

et al. 2005

Journal of Magnetic Resonance

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Hyperpolarized 129 Xe can be used as a sensor to indirectly detect NMR spectra of heteronuclei that are neither covalently bound nor necessarily in direct contact with the Xe atoms, but coupled through long-range intermolecular dipolar couplings. In order to reintroduce long-range dipolar couplings the sample symmetry has to be broken. This can be done either by an asymmetric sample arrangement, or by breaking the symmetry of the spin magnetization with field gradient pulses. Experiments are performed where only a small fraction of the available 129 Xe magnetization is used for each point, so that a single batch of xenon suffices for the point-by-point acquisition of a heteronuclear NMR spectrum. Examples with 1 H as analyte nucleus show that these methods have the potential to obtain spectra with a resolution that is high enough to determine homonuclear J couplings. The applicability of this technique with remote detection is discussed.

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Nuclear Magnetic Resonance of Laser-Polarized Noble Gases in Molecules, Materials, and Organisms

Cited by 415 publications

References 236 publications

Remotely detected high-field MRI of porous samples

Remotely detected high-field MRI of porous samples

Functional Imaging: CT and MRI

NMR detection using laser-polarized xenon as a dipolar sensor

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