Nuclear magnetic resonance imaging with hyperpolarised helium-3

Ebert, M.; Großmann, T.; Heil, W.; Otten, Ernst W.; Surkau, R.; Thelen, M.; Leduc, Michèle; Bachert, Peter; Knopp, M.V.; Schad, Lothar R.

doi:10.1016/s0140-6736(96)90940-x

Cited by 184 publications

(144 citation statements)

References 9 publications

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“…[32]), but this is not exact for a real gas. For helium ( 3 He, 4 He and isotope mixtures), the computed values in the 200-600 K range [30] can be accurately reproduced (within 0.2%) by a power law D i (T ) ∝ T 1.71 . For a binary mixture in which 3 He (with negligible partial pressure) diffuses in another component i, D 3i is given by Eq.…”

Section: B Value Of D In Several Gas Mixturesmentioning

confidence: 72%

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In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

Bidinosti¹,

Choukeife²,

Nacher³

et al. 2003

Journal of Magnetic Resonance

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We present NMR measurements of the diffusion of hyperpolarized 3 He in the human lung performed at fields much lower than those of conventional MRI scanners. The measurements were made on standing subjects using homebuilt apparatus operating at 3 mT. O 2 -limited transverse relaxation (T 2 up to 15-35 s) could be measured invivo. Accurate global diffusion measurements have been performed in-vivo and in a plastic bag; the average apparent diffusion coefficient (ADC) in-vivo was 14.2 ± 0.6 mm 2 /s, whereas the diffusion coefficient in the bag ( 3 He diluted in N 2 ) was 79.5 ± 1 mm 2 /s. 1D ADC mapping with high SNR (∼ 200 -300) demonstrates the real possibility of performing quality lung imaging at extremely low fields.

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Section: B Value Of D In Several Gas Mixturesmentioning

confidence: 72%

“…In-vivo studies on the human lung began in 1996 using conventional clinical systems operating at 0.8 T [4,5] and 1.5 T [6]. However, unlike conventional MRI, the strong field is not needed here to polarize the gas.…”

Section: Introductionmentioning

confidence: 99%

In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

Bidinosti¹,

Choukeife²,

Nacher³

et al. 2003

Journal of Magnetic Resonance

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“…A single-shot, spin-echo sequence (RARE) was used to make maximum efficiency of the polarization [6]. The 3 mT image is of modest quality: similar to the pioneering 1.5 T images made seven years ago [9], yet a marked improvement from the first very low field image at 15 mT which suffered from poorly shielded external noise [4]. Still, we anticipate that image quality will quickly improve with better control over other noise sources (via improved low frequency filtering of lines into Faraday cage) and the use of larger quantities of He gas is used, SNR values up to 1000 will become routine, thereby allowing P o and R to be reliably extracted with a few seconds of data only (this is shown in the inset panels of Figure 3 for simulated data).…”

Section: D Projection Imagingmentioning

confidence: 99%

MRI of the lung using hyperpolarized 3 He at very low magnetic field (3 mT)

Bidinosti

Choukeife

Tastevin

et al. 2004

MAGMA Magnetic Resonance Materials in Physics, Biology and Medi

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Conference: ISMRM meeting, Toronto 2003.Optical pumping of 3 He produces large (hyper) nuclear-spin polarizations independent of the magnetic resonance imaging (MRI) field strength. This allows lung MRI to be performed at reduced fields with many associated benefits, such as lower tissue susceptibility gradients and decreased power absorption rates. Here we present results of 2D imaging as well as accurate 1D gas diffusion mapping of the human lung using 3 He at very low field (3 mT). Furthermore, measurements of transverse relaxation in zero applied gradient are shown to accurately track pulmonary O 2 partial pressure, opening the way for novel imaging sequences.

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“…For NMR and magnetic resonance imaging (MRI), [1][2][3][4] the production of hyperpolarized noble gases through spin-exchange with optically pumped alkali-metal atoms, 5 has gained importance. For some potential applications such as 129 Xe imaging of the brain, 4 very high nuclear polarizations are required to circumvent the limitations of the delivery method 6 and to avoid the anaesthetic effects of large quantities of Xe in the brain.…”

Section: à5mentioning

confidence: 99%

Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized 129Xe

Shah¹,

Ünlü²,

Wegener

et al. 2000

NMR Biomed.

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We report on a rubidium-xenon (Rb-Xe) polarization unit for the continuous production of large quantities of hyperpolarized 129 Xe. The unit includes two diagnostic systems which enable the absolute measurement of both the 85 Rb and 129 Xe polarization in situ and at high temperatures. The Rb diagnostic system allows the measurement of one-or two-dimensional images of the absolute Rb polarization and thus enables the experimental study of light penetration into the optical pumping cell. The equilibrium Xe polarization measured in the optical pumping cell and in the freezing unit is typically $20%, under optimal flowing conditions, and this is much lower than the volume-averaged rubidium polarization.

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Nuclear magnetic resonance imaging with hyperpolarised helium-3

Cited by 184 publications

References 9 publications

In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

MRI of the lung using hyperpolarized 3 He at very low magnetic field (3 mT)

Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized 129Xe

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