Nuclear magnetic resonance analysis of water in natural and deuterated mouse muscle above and below freezing

Peemoeller, H.; Pintar, M. M.; Kydon, D. W.

doi:10.1016/s0006-3495(80)85144-7

Cited by 28 publications

(13 citation statements)

References 16 publications

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“…The FID and T2 results in muscle agree with the published data (12,23,24). The SS-component, which was deduced indirectly a few years ago from measurements in fully deuterated muscle (24), is resolved in the present experiment in the natural muscle.…”

Section: Resultssupporting

confidence: 90%

“…In these studies, the NMR relaxation measurements have been taken at only one time window on the free induction decay (FID). The resolution of the heterogenous spin distribution was improved if the relaxation measurements were taken at two time windows (23,24). A further improvement of the resolution of spin distributions in these complex systems was achieved by a two-dimensional (2D) NMR technique (38,39).…”

Section: Introductionmentioning

confidence: 99%

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Improved Characterization of Healthy and Malignant Tissue by NMR Line-Shape Relaxation Correlations

Peemoeller¹,

Shenoy²,

Pintar³

et al. 1982

Biophysical Journal

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We performed a relaxation-line-shape correlation NMR experiment on muscle, liver, kidney, and spleen tissues of healthy mice and of mouse tumor tissue. In each tissue studied, five spin groups were resolved and characterized by their relaxation parameters. We report a previously uncharacterized semi-solid spin group and discuss briefly the value of this method for the identification of malignant tissues.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Improved Characterization of Healthy and Malignant Tissue by NMR Line-Shape Relaxation Correlations

Peemoeller¹,

Shenoy²,

Pintar³

et al. 1982

Biophysical Journal

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“…The values given by Kiricuta and Hazlewood (13, 1) correspond to the values for our T2, Component values. Careful measurements of a number of investigators on muscle from a variety of species have demonstrated that there exist three or more compartments (3, 14). These authors gave relaxation spin-spin times of water in the range from 30 to 500 ms.…”

Section: Discussionmentioning

confidence: 99%

NMR compartmentalization of free water in the perfused rat heart

Mauss

Grucker

Fornasiero

et al. 1985

Magnetic Resonance in Med

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Spin-lattice (T1) and spin-spin (T2) relaxation times have been measured on perfused rat hearts under two experimental conditions. T1 exhibits a monoexponential decay. On the other hand T2 has a decay with two components: a short one T2s and a long one T2l. These facts have been discussed according to cross-relaxation and a bicompartmentalization of tissue assuming a slow exchange model for spin-spin relaxation and a fast exchange model for spin-lattice relaxation. Increasing the osmotic pressure of the perfusion solution decreased the absolute density proton of the T2s compartment reflecting the loss of its water content. The paramagnetic ion manganese diminishes the values of T1 and those of the long component T2l without affecting its short component. Therefore the short component could be assigned to intracellular and the long component to extracellular free water. The extracellular T2 (459 ms) is approximatively 10-fold higher than the intracellular T2 (45 ms). With images of "pure T2" such a difference could be useful to enhance the contrast between organs and the surrounding liquid or between organs with different water compartmentalization.

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“…Many investigators have examined the contributions of a variety of different environments to the NMR relaxation properties of water molecules in biological systems (32)(33)(34)(35). Although the mechanisms for alteration of the proton Tl and Tz relaxation times by pharmaceuticals may be complex, a few general conclusions may be drawn.…”

Section: Discusslohmentioning

confidence: 99%

Common pharmaceuticals alter tissue proton NMR relaxation properties

Karlik

1986

Magnetic Resonance in Med

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Differences in the tissue properties of water are the basis for the detailed anatomic visualization of internal body structures produced by NMR imaging. Physiological and pathological events have the potential to alter proton nuclear magnetic resonance relaxation properties through changes in water environment. In this study, the parenteral injection of pharmaceuticals produced significant changes (12-21%) in proton NMR relaxation times in tissues of treated rats. The extent of relaxation time change was both tissue specific and drug specific. Therefore, the effects of common pharmaceuticals should be considered in the interpretation of T1- and T2-weighted NMR images.

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Nuclear magnetic resonance analysis of water in natural and deuterated mouse muscle above and below freezing

Cited by 28 publications

References 16 publications

Improved Characterization of Healthy and Malignant Tissue by NMR Line-Shape Relaxation Correlations

Improved Characterization of Healthy and Malignant Tissue by NMR Line-Shape Relaxation Correlations

NMR compartmentalization of free water in the perfused rat heart

Common pharmaceuticals alter tissue proton NMR relaxation properties

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